Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III
European Heart Journal - Quality of Care and Clinical Outcomes
Abstract
The risk of pregnancy in women with heritable thoracic aortic disease (HTAD) is estimated to be high, but supporting data are scarce. The aim of this study is to prospectively investigate pregnancy outcomes to improve patient management and care.
The Registry of Pregnancy and Cardiac disease (ROPAC) III is a prospective global registry including pregnant women with known aortic pathology between 2018 and 2023. Cardiac, obstetric and fetal outcomes, beta-blocker use, and the impact of breastfeeding were investigated. Additionally, changes in aortic diameters were assessed. In total, 176 pregnancies in 170 women (mean age 32 years, 56% primigravida) with HTAD were included: 122 with Marfan syndrome, 14 with Loeys–Dietz syndrome, 10 with
The aortic dissection rate in this cohort of women with HTAD diagnosis prior to pregnancy, under surveillance in specialized clinics, was lower than previously reported. Our results suggest that pregnancy might have some effect on aortic growth and dissections did occur. This warrants close monitoring, also after delivery. Importantly, we found no association between breastfeeding and post-partum complications.
Contributors
Puck N J Peters
Author
Guillaume Jondeau
Author
Osama Ahmad
Author
Marjorie Richardson
Author
Francesca M Comoglio
Author
Heleen van der Zwaan
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Siddharth K Prakash
Author
Roger Hall
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Mark R Johnson
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K Vardanyan
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A Melkonyan
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H Lachikyan
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K Hakobyan
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M Mazmanian
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H Hayrapetyan
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A Tavaracyan
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H Poghosyan
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R Hovhannisyan
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S Sahakyan
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S Martirosyan
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J Harris
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A Pasquet
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M Morissens
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T Besse-Hammer
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B Dumoulin
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J De Backer
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L Campens
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L Demulier
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M De Hosson
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W Budts
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A Van de Bruaene
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A Rampelberg
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E Troost
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L Roggen
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P De Meester
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J C Mwita
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E Tefera
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L Kontle
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A Marelli
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I Malhamé
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J Grewal
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M Janzen
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P A Román Rubio
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R Vasallo Peraza
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G Vázquez Hernández
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J E Pérez Torga
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Y Gil Jiménez
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M Meluzá Martín
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R Almaleh
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G Youssef
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K Sorour
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S Abebe
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D Mekonnen
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C Fekadu
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D Yadeta
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S Dupuis-Girod
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L Delagrange
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M Richardson
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L Ghesquiere
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O Domanski
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M Gonzalez Estevez
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Y Ould Hamoud
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S Gautier
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L Marsili
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L Bal-Theoleyre
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S Palazzolo
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M Ladouceur
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G Jondeau
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A Bourgeois Moine
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