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SGK1 inhibition shortens action potential duration and exerts anti-arrhythmic effects in LQT3 mice and LQT2 rabbits by reducing enhanced late sodium current

31 August 2025 (13:25 - 13:35)
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Congress Presentation Part of: Molecular and cellular drivers of arrhythmia Ion Channels, Electrophysiology ESC Professional Premium Access ESC Congress 2025 European Society of Cardiology

About the speaker

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Doctor Simona Casini

Amsterdam University Medical Centre (AUMC), Amsterdam (Netherlands (The))

4 More presentations in this session

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Investigation of a novel SLC4A3 variant causing short QT Syndrome: functional and pharmacological evaluation in a knock-in zebrafish model
Ms M. Zhu (Suita, JP)
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DECA11 selectively increases human INa and IK1 and is antiarrhythmic in a mouse model of heart failure
Professor R. Caballero (Madrid, ES)
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Atrial electrophysiological disturbances caused by disruption of the RBM20 splicing factor
Mr L. Weirauch (Heidelberg, DE)
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Engineered pluripotent stem cell-derived cardiomyocytes prevent serious engraftment-related arrhythmia in nonhuman primates
Associate Professor K. Nakamura (Seattle, US)
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Molecular and cellular drivers of arrhythmia
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The Event

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ESC Congress 2025

31 August 2025 13:25 CET
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