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Developing p21-activated kinase 1 (PAK1) activators to treat hypertrophic cardiomyopathy (HCM)

31 August 2024 (14:05 - 14:15)
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Congress Presentation Part of: Biotherapies in cardiovascular disease: from bench to bedside Cardiovascular Pharmacotherapy ESC Professional Premium Access ESC Congress 2024 European Society of Cardiology

About the speaker

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Doctor Yu He

University of Oxford, Oxford (United Kingdom of Great Britain & Northern Ireland)

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RKER-012, a novel modified ActRIIB ligand trap, attenuated right ventricular cardiomyopathy in a preclinical model of pulmonary arterial hypertension.
Doctor P. Jain (Lexington, US) Doctor K. Babbs (US)
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First-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of RBD4059, a GalNAc-siRNA drug targeting coagulation factor XI (FXI), in healthy subjects
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Preclinical characterisation and first-in-human results on the tolerability and pharmacodynamic effect of REGN9933, a monoclonal antibody targeting the factor XI/activated factor XI apple 2 domain
Doctor A. Kithcart (US)
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Phase I results of both IV and oral administration for CG-0255: a novel fast-acting antiplatelet drug with a new activation pathway
Doctor X. Chen (Shanghai, CN)
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Biotherapies in cardiovascular disease: from bench to bedside
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The Event

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ESC Congress 2024

31 August 2024 14:05 CET
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