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Preclinical characterisation and first-in-human results on the tolerability and pharmacodynamic effect of REGN9933, a monoclonal antibody targeting the factor XI/activated factor XI apple 2 domain

30 August 2024 (08:00 - 17:30)
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Congress Presentation Part of: Biotherapies in cardiovascular disease: from bench to bedside Anticoagulants ESC Professional Premium Access ESC Congress 2024 European Society of Cardiology

About the speaker

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Doctor Aaron Kithcart

(United States of America)

5 More presentations in this session

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CS585, a novel prostacyclin receptor agonist, demonstrates sustained efficacy in vivo in the prevention of thrombosis
Professor M. Holinstat (Ann Arbor, US)
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RKER-012, a novel modified ActRIIB ligand trap, attenuated right ventricular cardiomyopathy in a preclinical model of pulmonary arterial hypertension.
Doctor P. Jain (Lexington, US) Doctor K. Babbs (US)
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First-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of RBD4059, a GalNAc-siRNA drug targeting coagulation factor XI (FXI), in healthy subjects
Doctor A. Gabrielsen (Gothenburg, SE)
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Phase I results of both IV and oral administration for CG-0255: a novel fast-acting antiplatelet drug with a new activation pathway
Doctor X. Chen (Shanghai, CN)
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Developing p21-activated kinase 1 (PAK1) activators to treat hypertrophic cardiomyopathy (HCM)
Miss Y. He (Oxford, GB)
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Biotherapies in cardiovascular disease: from bench to bedside
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The Event

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ESC Congress 2024

30 August - 2 September 2024
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novartis Explore sponsored resources