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Hyperglycemia epigenetically propels senescence-associated secretory phenotype of CD34 hematopoietic stem cells and their myeloid expansion into inflammatory monocyte subpopulations

Topic: Lipid Metabolism, Metabolic Syndrome, Diabetes

Congress Presentation

About the speaker

Doctor Giulia Damiano

Monzino Cardiology Centre, Milan (Italy)
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4 more presentations in this session

Elevation of CISD2 attenuates atrial aging

Speaker: Professor C. Yeh (Tao-Yuan, TW)


The senolytic agent Dasatinib reduces fat accumulation in the heart and bone marrow of type 2 diabetic, obese mice and adipogenesis of human bone marrow pericytes

Speaker: Ms Y. Gu (Bristol, GB)


Identification of cell-intrinsic effects of mutated circulating cells due to clonal hematopoiesis in patients with heart failure

Speaker: Assistant Professor W. Abplanalp (Frankfurt, DE)


Canagliflozin enhances endogenous eliminatiton of senescent cells through downregulation of PD-L1

Speaker: Doctor G. Katsuumi (Tokyo, JP)


Access the full session

Ageing, clonal, haematopoiesis and senescence

Speakers: Doctor G. Damiano, Professor C. Yeh, Ms Y. Gu, Assistant Professor W. Abplanalp, Doctor G. Katsuumi

About the event


ESC Congress 2023

25 August - 28 August 2023

Sessions Presentations

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