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The KCa2 channel inhibitor AP14145, but not dofetilide or ondansetron, provides functional atrial selectivity in guinea pig hearts

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Associate Professor Nils Edvardsson

Sahlgrenska University Hospital, Gothenburg (Sweden)
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8 more presentations in this session

Mechanisms of action of the small conductance Ca2+-activated K+-channel modulator AP30663, a novel compound being developed for treatment of atrial fibrillation in man

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The SK channel inhibitor AP30663, converts vernakalant-resistant persistent AF and prevents its reinduction in pigs

Speaker: Doctor J. Diness (Copenhagen, DK)


The role of a phosphoinositide-3 kinase inhibitor in vascular inflammation

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The small conductance Ca2+-activated K+-channel inhibition tool compound AP14145 protected the guinea pig heart from ventricular arrhythmia during hypokalemia whereas dofetilide was pro-arrhythmic

Speaker: Professor M. Grunnet (Copenhagen N, DK)


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Poster Session 1 - Preclinical pharmacotherapy

Speakers: Associate Professor N. Edvardsson, Mrs S. Bomholtz, Doctor J. Diness, Miss H. Chaudhry, Associate Professor H. Pan...

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ESC Congress 2019

31 August - 4 September 2019

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