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The KCa2 channel inhibitor AP14145, but not dofetilide or ondansetron, provides functional atrial selectivity in guinea pig hearts

31 August 2019 (00:00 - 00:00)
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Congress Presentation Part of: Poster Session 1 - Preclinical pharmacotherapy Antiarrhythmic Pharmacotherapy ESC Premium Access ESC Congress 2019

About the speaker

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Associate Professor Nils Edvardsson

Sahlgrenska University Hospital, Gothenburg (Sweden)

8 More presentations in this session

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Mechanisms of action of the small conductance Ca2+-activated K+-channel modulator AP30663, a novel compound being developed for treatment of atrial fibrillation in man
Mrs S. Bomholtz (Copenhagen N, DK)
Abstract Slides
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The SK channel inhibitor AP30663, converts vernakalant-resistant persistent AF and prevents its reinduction in pigs
Doctor J. Diness (Frederiksberg, DK)
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The role of a phosphoinositide-3 kinase inhibitor in vascular inflammation
Miss H. Chaudhry (London, GB)
Abstract Slides
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Anti-thrombin nanoparticles for reduce vascular damage and promote functional recovery in acute ischemic kidney injury well after reperfusion
Associate Professor H. Pan (Saint Louis, US)
Abstract
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The small conductance Ca2+-activated K+-channel inhibition tool compound AP14145 protected the guinea pig heart from ventricular arrhythmia during hypokalemia whereas dofetilide was pro-arrhythmic
Professor M. Grunnet (Copenhagen N, DK)
Abstract

Access the full session

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Poster Session 1 - Preclinical pharmacotherapy

The Event

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ESC Congress 2019

31 August - 4 September 2019
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