Impact of anthropometric factors on outcomes in atrial fibrillation patients: analysis on 10 220 patients from the European Society of Cardiology (ESC)-European Heart Rhythm Association (EHRA) EurObservational Research Programme on Atrial Fibrillation (EORP-AF) general long-term registry
European Journal of Preventive Cardiology

Abstract
To investigate the association of anthropometric parameters [height, weight, body mass index (BMI), body surface area (BSA), and lean body mass (LBM)] with outcomes in atrial fibrillation (AF).
Ten-thousand two-hundred twenty patients were enrolled [40.3% females, median age 70 (62–77) years, followed for 728 (interquartile range 653–745) days]. Sex-specific tertiles were considered for the five anthropometric variables. At the end of follow-up, survival free from all-cause death was worse in the lowest tertiles for all the anthropometric variables analyzed. On multivariable Cox regression analysis, an independent association with all-cause death was found for the lowest vs. middle tertile when body weight (hazard ratio [HR] 1.66, 95%CI 1.23–2.23), BMI (HR 1.65, 95%CI 1.23–2.21), and BSA (HR 1.49, 95%CI 1.11–2.01) were analysed in female sex, as well as for body weight in male patients (HR 1.61, 95%CI 1.25–2.07). Conversely, the risk of MACE was lower for the highest tertile (vs. middle tertile) of BSA and LBM in males and for the highest tertile of weight and BSA in female patients. A higher occurrence of haemorrhagic events was found for female patients in the lowest tertile of height [odds ratio (OR) 1.90, 95%CI 1.23–2.94] and LBM (OR 2.13, 95%CI 1.40–3.26).
In AF patients height, weight, BMI, BSA, and LBM were associated with clinical outcomes, with all-cause death being higher for patients presenting lower values of these variables, i.e. in the lowest tertiles of distribution. The anthropometric variables independently associated with other outcomes were also different between male and female subjects.
Contributors

O Deceuninck
Author

O Xhaet
Author

F Dormal
Author

E Ballant
Author

D Blommaert
Author

D Yakova
Author

A Olejnik
Author

L Benham
Author

M Hristov
Author

R Brady
Author

E Harc-Dyl
Author

Marco Vitolo
Author

T Yncheva
Author

N Stancheva
Author

Vincenzo L Malavasi
Author

L Buchanan
Author

A Ashton
Author

H Crowther
Author

H Fairlamb
Author

S Thornthwaite
Author

C Relph
Author

A McSkeane
Author

J Miarka
Author

U Poultney
Author

S Tisheva
Author

N Kelsall
Author

M Pasieka
Author

Elisa Fantecchi
Author

P Rice
Author

M Ziemińska-Łuć
Author

W Bujak
Author

M Tokmakova
Author

Igor Diemberger
Author

A Śliwiński
Author

T Wilson
Author

F Nikolov
Author

Francisco Marin
Author

A Grech
Author

D Gencheva
Author

M Wrigley
Author

Michael Nabauer
Author

J Morka
Author

T Shalganov
Author

R Kaba
Author

T Patel
Author

Tatjana S Potpara
Author

K Petrykowska
Author

B Kunev
Author

E Young
Author

Gheorghe-Andrei Dan
Author

M Prasał
Author

M Stoyanov
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J Law
Author

C Runnett
Author

Zbigniew Kalarus
Author

D Marchov
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G Hordyński
Author

H Thomas
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V Gelev
Author

Luigi Tavazzi
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P Feusette
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P Lipski
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H McKie
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V Traykov
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A Wester
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Aldo Pietro Maggioni
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J Fuller
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A Kisheva
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W Streb
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Deirdre A Lane
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Gregory Y H Lip
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S Pick
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A Sharp
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H Tsvyatkov
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G Boriani
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R Shtereva
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J Romanek
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G Y H Lip
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S Bakalska-Georgieva
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S Slavcheva
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A Hunt
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K Thorpe
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L Tavazzi
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Y Yotov
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M Chlebuś
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P Szafarz
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M Kubíčková
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W Stanik
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C Hardman
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M Pavlovic
Author

C Zoccali
Author

N Panic-Jelic
Author

O Vujadinovic
Author

V L Malavasi
Author

A Mussagaliyeva
Author

B Ahyt
Author

P Pajic
Author

Z Salihova
Author

S Bekic
Author

S Kovacevic
Author

A García Fernandez
Author

A Perez Cabeza
Author

M Anguita
Author

L Tercedor Sanchez
Author

K Koshum-Bayeva
Author

A Kerimkulova
Author

A Bairamukova
Author

E Mau
Author

J Loayssa
Author

M Ayarra
Author

M Carpintero
Author

I Roldán Rabadan
Author

M Leal
Author

M Gil Ortega
Author

E Mirrakhimov
Author

A Tello Montoliu
Author

B Lurina
Author

E Orenes Piñero
Author

R Zuzans
Author

S Manzano Fernández
Author

F Marín
Author

A Romero Aniorte
Author

A Veliz Martínez
Author

S Jegere
Author

I Mintale
Author

M Quintana Giner
Author

G Ballesteros
Author

K Kupics
Author

K Jubele
Author

A Erglis
Author

M Palacio
Author

O Alcalde
Author

I García-Bolao
Author

O Kalejs
Author

V Bertomeu Gonzalez
Author

K Vanhear
Author

F Otero-Raviña
Author

J García Seara
Author

J Gonzalez Juanatey
Author

N Dayal
Author

P Maziarski
Author

M Burg
Author

M Cachia
Author

P Gentil-Baron
Author

E Abela
Author

S Warwicker
Author

D Shah
Author

M Koç
Author

E Onrat
Author

I E Dural
Author

K Yilmaz
Author

B Özin
Author

T Tabone
Author

R Xuereb
Author

S Tan Kurklu
Author

Y Atmaca
Author

U Canpolat
Author

L Tokgozoglu
Author

D Asanovic
Author

A K Dolu
Author

B Demirtas
Author

D Sahin
Author

D Drakalovic
Author

O Ozcan Celebi
Author

E Diker
Author

M Vukmirovic
Author

N Pavlovic
Author

G Gagirci
Author

L Music
Author

U O Turk
Author

H Ari
Author

N Polat
Author

N Toprak
Author

M Sucu
Author

O Akin Serdar
Author

A Taha Alper
Author

N Bulatovic
Author

A Boskovic
Author

A Kepez
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Y Yuksel
Author

A Uzunselvi
Author

H Uiterwaal
Author

N Bijsterveld
Author

S Yuksel
Author

M Sahin
Author

J De Groot
Author

J Neefs
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O Kayapinar
Author

T Ozcan
Author

H Kaya
Author

N van den Berg
Author

F Piersma
Author

M B Yilmaz
Author

A Wilde
Author

V Hagens
Author

M Kutlu
Author

J Van Es
Author

M Demir
Author

C Gibbs
Author

S Kaminskiene
Author

J Van Opstal
Author

B Van Rennes
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H Verheij
Author

M Bryce
Author

A Skinner
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W Breukers
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G Tjeerdsma
Author

R Nijmeijer
Author

G Belcher
Author

J Hunt
Author

D Wegink
Author

R Binnema
Author

S Said
Author

L Stancombe
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B Holbrook
Author

Ö Erküner
Author

C Peters
Author

S Tettersell
Author

A Shantsila
Author

D Lane
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K Senoo
Author

S Philippens
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M Proietti
Author

K Russell
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P Domingos
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S Hussain
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W van Doorn
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H Crijns
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T Szili-Torok
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J Partridge
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R Haynes
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S Bahadur
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R Brown
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R Bhagwandien
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P Janse
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S McMahon
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G Y H Lip
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J McDonald
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K Balachandran
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R Singh
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S Garg
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A Muskens
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H Desai
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K Davies
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M van Eck
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R Gevers
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N van der Ven
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A Duygun
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W Goddard
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B Rahel
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J Meeder
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A Vold
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C Holst Hansen
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I Engset
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G Galasko
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I Rahman
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Y Chua
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O Payne
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D Atar
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S Preston
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B Dyduch-Fejklowicz
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E Koba
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O Brennan
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L Pedley
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C Whiteside
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C Dickinson
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J Brown
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K Jones
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M Cichocka
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A Sokal
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A Kubicius
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E Pruchniewicz
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A Kowalik-Sztylc
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W Czapla
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I Mróz
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M Kozlowski
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T Pawlowski
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M Tendera
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A Winiarska-Filipek
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A Fidyk
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A Slowikowski
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M Haberka
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M Lachor-Broda
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M Biedron
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Z Gasior
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M Kołodziej
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M Janion
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I Gorczyca-Michta
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B Wozakowska-Kaplon
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M Stasiak
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P Jakubowski
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T Ciurus
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J Drozdz
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M Simiera
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P Zajac
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T Wcislo
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P Zycinski
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J Kasprzak
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