Prognostic impact of regurgitant volume to left atrial volume ratio on ventricular functional mitral regurgitation
European Heart Journal - Cardiovascular Imaging
Abstract
In patients with ventricular functional mitral regurgitation (VFMR) undergoing transcatheter edge-to-edge repair (M-TEER), the prognostic significance of the ratio between mitral regurgitant volume and left atrial volume (LAV) remains unclear. This ratio may reflect the proportional or disproportionate burden of regurgitation on the left atrium. To address this gap, we aimed to investigate the association between the regurgitant volume (RVol)/LAV ratio and clinical outcomes in patients with VFMR, using data from a multicentre prospective registry.
We calculated the RVol/LAV ratio from baseline transthoracic echocardiograms. The median value of the RVol/LAV ratio was 0.40. A total of 1830 patients who underwent M-TEER were allocated into two groups: the low RVol/LAV (RVol/LAV ratio <0.40) and high RVol/LAV (RVol/LAV ratio ≥0.40) groups. The primary endpoint was heart failure hospitalization. Eight hundred eighty-eight and 942 patients were included into the low RVol/LAV ratio and high RVol/LAV ratio groups, respectively. The median follow-up period was 508 days. At 3 years after repair, 215 (37.6%) and 187 (32.1%) patients in the low RVol/LAV and high RVol/LAV groups, respectively, were hospitalized for heart failure. The patients in the low RVol/LAV group demonstrated a significantly higher risk of heart failure hospitalization than did those in the high RVol/LAV group (hazards ratio, 1.25; 95% confidence interval, 1.03–1.52;
The RVol/LAV ratio might serve as a valuable metric for improving risk stratification in patients with VFMR.
OCEAN Mitral registry (UMIN ID: UMIN000023653)
Contributors
Masahiro Inagaki
Author
Shinichiro Doi
Author
Hirooki Higami
Author
Ryota Nishio
Author
Masafumi Yoshikawa
Author
Nobuyuki Kagiyama
Author
Yoji Kuze
Author
Tomohiro Kaneko
Author
Takanori Kawamoto
Author
Takashi Nagai
Author
Sakiko Miyazaki
Author
Eiji Shibahashi
Author
Azusa Kurita
Author
Norihito Takahashi
Author
Daisuke Hachinohe
Author
Yusuke Inagaki
Author
Shinichi Shirai
Author
Ken Kobayashi
Author
Chihiro Saito-Koyanagi
Author
Akihiro Isotani
Author
Kazuki Mizutani
Author
Hidemasa Shitan
Author
Tomohito Kogure
Author
Ryo Horita
Author
Kenichi Ishizu
Author
Junichi Yamaguchi
Author
Ryo Otakedaisuke Hachinohe
Author
Masato Fukunaga
Author
Masanori Yamamoto
Author
Shunsuke Kubo
Author
Ken Kobayashi
Author
Hiroyuki Tabata
Author
Yuki Izumi
Author
Kazuki Mizutani
Author
Toru Morofuji
Author
Hidemasa Shitan
Author
Yusuke Enta
Author
Hiroyuki Kono
Author
Ryo Horita
Author
Ryo Otake
Author
Shinichi Shirai
Author
Mike Saji
Author
Maiko Kuroda
Author
Masaki Izumo
Author
Shingo Mizuno
Author
Hiroshi Ohara
Author
Yusuke Watanabe
Author
Euihong Ko
Author
Hideki Koikemike Saji
Author
Makoto Amaki
Author
Norihisa Miyawaki
Author
Hiroshi Ohara
Author
Hideki Koike
Author
Kazuhisa Kodama
Author
Kenji Nakano
Author
Toru Naganuma
Author
Katsunori Miyahara
Author
Hiroki Bota
Author
Ko Yamamoto
Author
Koumei Onuki
Author
Yohei Ohno
Author
Yasuo Tsuru
Author
Daisuke Hachinohe
Author
Masahiro Yamawaki
Author
Tomohiro Suenaga
Author
Akira Otanishinichi Shirai
Author
Hiroshi Ueno
Author
Gaku Nakazawa
Author
Akihiro Isotani
Author
Toshiaki Otsuka
Author
Kenichi Ishizu
Author
Masato Fukunaga
Author
Hiroyuki Tabata
Author
Kentaro Hayashida
Author
Makoto Tanaka
Author
Toru Morofuji
Author
Hikaru Tsuruta
Author
Hiroyuki Kono
Author
Maiko Kuroda
Author
Euihong Ko
Author
Norihisa Miyawaki
Author
Kenji Nakano
Author
Katsunori Miyahara
Author
Ko Yamamoto
Author
Koumei Onuki
Author
Yasuo Tsuru
Author
Tomohiro Suenaga
Author
Akira Otani
Author
Taiga Katayama
Author
Hirofumi Hioki
Author
Junichi Nishikawa
Author
Yosei Iseki
Author
Yasuyuki Tsuchida
Author
Kento Kito
Author
Joe Omiya
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Masataka Arakawa
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Tetsuya Saito
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Yusuke Kobari
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Toshinobu Ryuzaki
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Maki Okamoto
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Tatsuo Takahashi
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Masafumi Saito
Author
Mizuki Miurawatanabe
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Shinichi Goto
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Taiga Katayama
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Shohei Imaeda
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Hirofumi Hioki
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Shingo Sakata
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Junichi Nishikawa
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Yosei Iseki
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Yoshinori Katsumata
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Yasuyuki Tsuchida
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Kohsuke Shirakawa
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Juri Iwata
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Keitaro Shinada
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Akiyoshi Kajino
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Kento Kito
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Joe Omiya
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Jungo Kato
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Masataka Arakawa
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Maki Okamoto
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Ryo Arita
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Masafumi Saito
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Toru Naganuma
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Makoto Tanaka
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Hikaru Tsuruta
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Toru Ouchi
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Tetsuya Saito
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Haruhito Yukitoru Naganuma
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Yusuke Kobari
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Toru Ouchi
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Haruhito Yuki
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Toshinobu Ryuzaki
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Tatsuo Takahashi
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Shinichi Goto
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Yusuke Enta
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Shohei Imaeda
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Shingo Sakata
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Norio Tada
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Yoshinori Katsumata
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Masaki Nakashima
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Kohsuke Shirakawa
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Juri Iwata
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Makoto Saigan
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Keitaro Shinada
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Akiyoshi Kajino
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Yoshiko Munehisa
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Masaki Miyasaka
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Jungo Kato
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Natsuko Satomi
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Yuta Kobayashi
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Ryo Arita
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Tomonari Moriizumi
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Daishi Tazawa
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Yun Tengyusuke Enta
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Masanori Yamamoto
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Norio Tada
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Mitsuru Sago
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Masaki Nakashima
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Tatsuya Tsunaki
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Makoto Saigan
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Ryo Yamaguchi
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Yoshiko Munehisa
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Junji Yanagisawa
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Masaki Miyasaka
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Yuki Okubomasanori Yamamoto
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Mitsuru Sago
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Tatsuya Tsunaki
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Ryo Yamaguchi
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Natsuko Satomi
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Junji Yanagisawa
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Yuta Kobayashi
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Yuki Okubo
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Ai Kagase
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Takahiro Tokuda
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Yuki Nakashima
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Daishi Tazawa
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Toshihiro Kobayashi
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Kenichi Shibata
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Yun Teng
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Shingo Mizuno
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Ryoutaku Kawahata
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Hiroto Nishio
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Futoshi Yamanaka
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Yuki Kondo
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Tomofumi Nakamura
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Hiroshi Tsunamotoai Kagase
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Koki Shishido
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Tomoki Ochiai
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Takahiro Tokuda
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Tsuyoshi Yamabe
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Yuki Nakashima
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Noriaki Moriyama
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Toshihiro Kobayashi
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Takashi Matsumoto
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Kenichi Shibata
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Hirokazu Miyashita
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Yoichi Sugiyama
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Kunihiko Shimizu
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Ryoutaku Kawahata
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Daisuke Sato
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Hiroto Nishio
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Yuka Murakamishingo Mizuno
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Yuki Kondo
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Futoshi Yamanaka
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Tomofumi Nakamura
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Koki Shishido
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Hiroshi Tsunamoto
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Tetsuro Shimura
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Yutaka Koyama
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Tomoki Ochiai
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Tsuyoshi Yamabe
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Munenori Okubo
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Noriaki Moriyama
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Shunsuke Imai
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Takashi Matsumoto
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Tokuya Sakakura
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Hirokazu Miyashita
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Yoshihiro Harano
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Yoichi Sugiyama
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Masahiro Inagaki
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Hirooki Higami
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Kunihiko Shimizu
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Yoji Kuze
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Daisuke Sato
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Takashi Nagai
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Azusa Kuritashimura
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Yuka Murakami
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Yutaka Koyama
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Hiroshi Ueno
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Munenori Okubo
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Shunsuke Imai
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Nobuyuki Fukuda
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Tokuya Sakakura
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Yoshihiro Harano
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Shuhei Tanaka
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Hiroshi Onoda
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Toshio Doi
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Mitsuo Sobajima
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Yohei Ueno
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Teruhiko Imamura
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Ryuichi Ushijima
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Yuki Hida
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Kazuya Nakashimahiroshi Ueno
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Nobuyuki Fukuda
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Shuhei Tanaka
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Hiroshi Onoda
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Toshio Doi
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Mitsuo Sobajima
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Yohei Ueno
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Teruhiko Imamura
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Ryuichi Ushijima
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Yuki Hida
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Kazuya Nakashima
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Yohei Ohno
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Junichi Miyamoto
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Tsutomu Murakami
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Sho Torii Makoto Natsumeda
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Shigemitsu Tanaka
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Takeshi Ijichi
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Hitomi Horinouchi
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Kazuki Aihara
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Katsuaki Sakai
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Shingo Matsumoto
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Norihiko Kamioka
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Norihito Nakamura
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Satoshi Noda
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Yu Satoyohei Ohno
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Junichi Miyamoto
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Tsutomu Murakami
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Sho Torii Makoto Natsumeda
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Shigemitsu Tanaka
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Takeshi Ijichi
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Hitomi Horinouchi
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Kazuki Aihara
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Katsuaki Sakai
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Shingo Matsumoto
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Norihiko Kamioka
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Norihito Nakamura
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Satoshi Noda
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Yu Sato
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Masaki Izumo
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Daisuke Miyahara
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Tomoyuki Tani
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Mamoru Miyazaki
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Hiroto Suzuyama
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Hideharu Okamatsu
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Tomohiro Sakamoto
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Yoko Horibata
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Yutaka Konami
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Masahiro Yamada
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Eiji Horio
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Mika Maeda
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Satoko Hasegawa
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Megumi Koga
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Mikiko Ohara
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Junichi Yamaguchi
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