Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
European Heart Journal
Abstract
Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through development of vascular damage. The study aimed to investigate whether accelerated vascular ageing occurs after COVID-19 infection, and if so, identify its determinants.
This prospective, multicentric, cohort study, included 34 centres in 16 countries worldwide, in 4 groups of participants—COVID-19-negative controls (ⅰ) and three groups of individuals with recent (6 ± 3 months) exposure to SARS-CoV-2: not hospitalized (ⅱ), hospitalized in general wards (ⅲ), and hospitalized in intensive care units (ⅳ). The main outcome was carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery stiffness.
2390 individuals (age 50 ± 15 years, 49.2% women) were recruited. After adjustment for confounders, all COVID-19-positive groups showed higher PWV (+0.41, +0.37, and +0.40 m/s for groups 2–4,
COVID-19 is associated with early vascular ageing in the long term, especially in women.
Contributors
Smriti Badhwar
Author
Mohsen Agharazii
Author
Fabio Anastasio
Author
Jeremy Bellien
Author
Otto Burghuber
Author
Luca Faconti
Author
King's College London London , United Kingdom of Great Britain & Northern Ireland
Jan Filipovsky
Author
Lorenzo Ghiadoni
Author
Cristina Giannattasio
Author
Bernhard Hametner
Author
Alun D Hughes
Author
Ana Jeroncic
Author
Ignatios Ikonomidis
Author
Alessandro Maloberti
Author
Christopher C Mayer
Author
Maria Lorenza Muiesan
Author
Anna Paini
Author
Chloe Park
Author
Chakravarthi Rajkumar
Author
Carlos Ramos Becerra
Author
Bart Spronck
Author
Yesim Tuncok
Author
Thomas Weber
Author
Pierre Boutouyrie
Author
Herta Almhofer
Author
Kathen Danninga
Author
Margot Algner
Author
Martin Wernhart
Author
Thomas Weber
Author
Bernhard Hametner
Author
Christopher C Mayer
Author
Otto Burghuber
Author
Mohammad Azizzadeh
Author
Marie-Kathrin Breyer
Author
Luiz Bortolotto
Author
Jose Fernando Vilela-Martin
Author
Rogério Toshiro Passos Okawa
Author
Weimar Kunz Sebba Barroso
Author
Emmanuel Gomes Ciolac
Author
Vanessa Teixeira do Amaral
Author
Bianca Fernandez
Author
Rémi Goupil
Author
Mohsen Agharazii
Author
Catherine Fortier
Author
Andrie G Panayiotou
Author
Galatia Photiou
Author
Jan Filipovský
Author
Otto Mayer
Author
Jitka Seidlerová
Author
Petr Pazdiora
Author
Jana Hirmerová
Author
Lucie Šustková
Author
Simona Bílková
Author
Július Gelžinský
Author
Veronika Kordíková
Author
Štěpán Mareš
Author
Renata Cífková
Author
Peter Wohlfahrt
Author
Jana Kavalírová
Author
Rosa Maria Bruno
Author
Pierre Boutouyrie
Author
Hakim Khettab
Author
Junior Justin
Author
Diego Moriconi
Author
Saverio Fabbri
Author
Jean Sebastien Hulot
Author
Antoine Fayol
Author
Marie Courbebaisse
Author
Beatrice Parfait
Author
David Lebeaux
Author
Gérard Friedlander
Author
Jeremy Bellien
Author
Robinson Joannides
Author
Michele Iacob
Author
Anne-Marie Leroi
Author
Athanase Benetos
Author
Ioannis Georgiopoulos
Author
Dimitrios Terentes-Printzios
Author
Georgia Christopoulou
Author
Konstantinos Tsioufis
Author
Vasiliki Gardikioti
Author
Charalambos Vlachopoulos
Author
Ignatios Ikonomidis
Author
Vaia Lambadiari
Author
Alkaternini Kountouri
Author
Konstantinos Katogiannis
Author
Ana Jerončić
Author
Mario Podrug
Author
Mirela Pavičić-Ivelja
Author
Pjero Koren
Author
Maria Lorenza Muiesan
Author
Anna Paini
Author
Massimo Salvetti
Author
Marco Cacciatore
Author
Giacomo Pucci
Author
Fabio Anastasio
Author
Elisa Scarnecchia
Author
Cristina Giannattasio
Author
Maloberti Alessandro
Author
Michela Algeri
Author
Antonella Moreo
Author
Chiara Tognola
Author
Andrea Grillo
Author
Bruno Fabris
Author
Stella Bernardi
Author
Matteo Rovina
Author
Giuliano Di Pierro
Author
Lorenzo Ghiadoni
Author
Sabina Armenia
Author
Elisabetta Bianchini
Author
Luca Zanoli
Author
Pietro Castellino
Author
Arturo Montineri
Author
Alice Sciuto
Author
Davide Grassi
Author
Jolita Badariene
Author
Ligita Ryliskyte
Author
Agne Laucyte-Cibulskiene
Author
Ligita Jancoriene
Author
Kristina Ryliskiene
Author
Agne Juceviciene
Author
Milda Kovaite
Author
Laura Balkeviciene
Author
Carlos G Ramos-Becerra
Author
Guillermos Alanis-Sánchez
Author
Pedro Martinez-Ayala
Author
Ernesto G Cardona-Muñóz
Author
David Cardona-Muller
Author
Mai Tone Lonnebakken
Author
Caroline Annette Berge
Author
Lucimere Bohn
Author
José Oliveira
Author
Emilia Alves
Author
Simao Pedro Costa
Author
Telmo Pereira
Author
Armando Caseiro
Author
Fábio Lira
Author
Maria Rosa Bernal López
Author
María Isabel Ruiz Moreno
Author
Ricardo Gómez Huelgas
Author
Almudena Lopez Sampalo
Author
Jaime Sanz Canovas
Author
Lidia Cobos Palacios
Author
Juan José Mancebo Sevilla
Author
Arzu Nazlı Zeka
Author
Ebru Özpelit
Author
Canet İncir
Author
Mustafa M Barış
Author
Yeşim Tunçok
Author
Ali Canturk
Author
Hasan Can Cimilli
Author
Leila Abid
Author
Salem Abdessalem
Author
Selma Charfeddine
Author
Amine Bahloul
Author
Rania Hammami
Author
Mahdi Walha
Author
Alun Hughes
Author
Chloe Park
Author
Alexandra Jamieson
Author
Philip J Chowienczyk
Author
Luca Faconti
Author
Bushra Farukh
Author
Riaz Akhtar
Author
Alena Shantsila
Author
Gregory Lip
Author
Alvaro N Gurovich
Author
Manuel Gomez
Author
Lee Stoner
Author
Michelle Meyer
Author
Erik Hanson
Author
Gabriel Zieff
Author
Patricia Pagan Lassalle
Author
Lauren Bates
Author
You may be interested in
