Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function
Cardiovascular Research
Abstract
While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.
Contributors
Inês Falcão Pires
Author
Christophe Beauloye
Author
Dana Dawson
Author
Nazha Hamdani
Author
Denise Hilfiker-Kleiner
Author
Linda W van Laake
Author
Frank Lezoualc’h
Author
Ida G Lunde
Author
Peter P Rainer
Author
Antonella Rispoli
Author
Valeria Visco
Author
Albino Carrizzo
Author
Davide Stolfo
Author
Jolanda van der Velden
Author
Serena Zacchigna
Author
Stephane Heymans
Author
Cardiovascular Research Institute Maastricht (CARIM) Maastricht , Netherlands (The)
Thomas Thum
Author
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