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Pharmacological modulation of cardiac senescence reveals divergent transcriptomic reversal patterns in human cardiomyocytes

30 August 2026 (16:15 - 17:00)
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Congress Presentation Part of: Ageing, senescence, and epigenetic regulation Stem Cells, Cell Cycle, Cell Senescence, Cell Death ESC2026 Premium Access ESC Congress 2026 European Society of Cardiology

About the speaker

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Doctor Kaspars Megnis

Latvian Biomedical Research and Study Centre (LBMC), Riga (Latvia)

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AI-driven prediction and experimental validation of nucleolin phase separation during aging
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E3 ubiquitin ligase targets nucleolin and modulates its phase separation to suppress ribosome biogenesis in myocardial infarction hearts
Professor Y. Li (Suzhou, CN)
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Targeting PERK-driven proteostasis signalling reveals spermidine-dependent stress resilience in the ageing heart
Ms N. Kanduri (SE)
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Oxidative dysregulation as central mechanisms of PANDA lncRNA in diabetic vasculature
Ms A. Mongelli (Schlieren, CH)
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Succinate induces histone succinylation to accelerate arterial calcification by activating FRA1/CREB3L2 axis
Doctor Z. Guan (Shenzhen, CN)
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Ageing, senescence, and epigenetic regulation

The Event

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ESC Congress 2026

30 August 2026 16:15 CET
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