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Pyruvate dehydrogenase kinase 4 Triggers VSMCs phenotype switching and aortic aneurysm/dissection by regulating NLRP3 lactylation

29 August 2026 (14:15 - 15:00)
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Congress Presentation Part of: Mechanistic insights into aortic diseases Pathophysiology and Mechanisms ESC2026 Premium Access ESC Congress 2026 European Society of Cardiology

About the speaker

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Associate Professor Di Yang

Fudan University, Shanghai (China)

6 More presentations in this session

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Hyperuricemia activates the TLR2–MAPK signaling axis in vascular macrophages to drive aortic dissection
Mr B. Zheng (Shenzhen, CN)
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Beyond chronological age: identifying accelerated aortic aging through laboratory indicators and geometric phenotyping
Doctor X. Duan (Kunming, CN)
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Attenuation of medial arterial calcification by senescent vascular smooth muscle cell clearance: a uPAR-targeted senolytic therapy
Miss M. Zhang (Shenzhen, CN)
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Pharmacological inhibition of microplastic uptake prevents endothelial injury
Doctor G. Tortorella (Naples, IT)
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GPR18 plays an atheroprotective role by regulating humoral and effector T-cell responses
Mrs A. Prabhu (Munich, DE)
Abstract Slides

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Mechanistic insights into aortic diseases

The Event

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ESC Congress 2026

29 August 2026 14:15 CET
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