Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
European Heart Journal - Quality of Care and Clinical Outcomes
Abstract
The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry.
1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (
Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
Contributors
Luis R Lopes
Author
Maria-Angela Losi
Author
Nabeel Sheikh
Author
Cécile Laroche
Author
Juan Gimeno
Author
E Zorio
Author
M A Arnau
Author
Juan P Kaski
Author
J Sanz
Author
E Marques-Sule
Author
Luigi Tavazzi
Author
Dulce Brito
Author
Jelena Celutkiene
Author
Albert Hagege
Author
Ales Linhart
Author
Jens Mogensen
Author
José Manuel Garcia-Pinilla
Author
Tomas Ripoll-Vera
Author
Hubert Seggewiss
Author
Eduardo Villacorta
Author
Perry M Elliott
Author
Christopher Peter Gale
Author
Branko Beleslin
Author
Andrzej Budaj
Author
Ovidiu Chioncel
Author
Nikolaos Dagres
Author
Nicolas Danchin
Author
David Erlinge
Author
Jonathan Emberson
Author
Michael Glikson
Author
Alastair Gray
Author
Meral Kayikcioglu
Author
Aldo Maggioni
Author
Klaudia Vivien Nagy
Author
Aleksandr Nedoshivin
Author
Anna-Sonia Petronio
Author
Jolien Roo Hesselink
Author
Lars Wallentin
Author
Uwe Zeymer
Author
Alida Caforio
Author
Juan Ramon Gimeno Blanes
Author
Philippe Charron
Author
Perry Elliott
Author
Juan Pablo Kaski
Author
Aldo P Maggioni
Author
Luigi Tavazzi
Author
Michal Tendera
Author
S Komissarova
Author
N Chakova
Author
S Niyazova
Author
A Linhart
Author
P Kuchynka
Author
T Palecek
Author
J Podzimkova
Author
M Fikrle
Author
E Nemecek
Author
H Bundgaard
Author
J Tfelt-Hansen
Author
J Theilade
Author
J J Thune
Author
A Axelsson
Author
J Mogensen
Author
F Henriksen
Author
T Hey
Author
S K Nielsen
Author
L Videbaek
Author
S Andreasen
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