Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size
Cardiovascular Research
Abstract
Identifying novel mediators of lethal myocardial reperfusion injury that can be targeted during primary percutaneous coronary intervention (PPCI) is key to limiting the progression of patients with ST-elevation myocardial infarction (STEMI) to heart failure. Here, we show through parallel clinical and integrative preclinical studies the significance of the protease cathepsin-L on cardiac function during reperfusion injury.
We found that direct cardiac release of cathepsin-L in STEMI patients (
Our findings suggest that cathepsin-L is a novel therapeutic target that could be exploited clinically to counteract the deleterious effects of acute reperfusion injury after an acute STEMI.
Contributors
Charlotte S McCarroll
Author
Katrin Nather
Author
Kristopher Ford
Author
Kenneth Mangion
Author
Golden Jubilee National Hospital Glasgow , United Kingdom of Great Britain & Northern Ireland
Alexandra Riddell
Author
Dylan O’Toole
Author
Ali Zaeri
Author
David Corcoran
Author
David Carrick
Author
Mathew M Y Lee
Author
University of Glasgow Glasgow , United Kingdom of Great Britain & Northern Ireland
Margaret McEntegart
Author
Andrew Davie
Author
Richard Good
Author
Mitchell M Lindsay
Author
Hany Eteiba
Author
Paul Rocchiccioli
Author
Stuart Watkins
Author
Stuart Hood
Author
Aadil Shaukat
Author
Lisa McArthur
Author
Elspeth B Elliott
Author
John McClure
Author
Catherine Hawksby
Author
Tamara Martin
Author
Mark C Petrie
Author
Keith G Oldroyd
Author
Godfrey L Smith
Author
Keith M Channon
Author
Colin Berry
Author
University of Glasgow Glasgow , United Kingdom of Great Britain & Northern Ireland
Stuart A Nicklin
Author
Christopher M Loughrey
Author
University of Glasgow Glasgow , United Kingdom of Great Britain & Northern Ireland
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