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SPAK regulates myocardial chloride homeostasis and drives dilated cardiomyopathy through mitochondrial dysfunction and energy metabolic disruption

30 August 2026 (14:42 - 14:54)
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Congress Presentation Part of: Mitochondrial function and metabolic remodelling in heart disease Mitochondria ESC2026 Premium Access ESC Congress 2026 European Society of Cardiology

About the speaker

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Doctor Shiyao Zhang

Xiamen Cardiovascular Hospital of Xiamen University, Xiamen (China)

4 More presentations in this session

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Von Willebrand factor a domain containing 8 (VWA8) is a mitochondria–ER spacer that restrains β-adrenergic–induced cardiac hypertrophy
Doctor H. Fan (Padova, IT)
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BHB-mediated ANT1 kbhb modification couples mitochondrial homeostasis to inflammatory suppression in ischaemic heart failure
Doctor A. Chen (Shanghai, CN)
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TMEM65 ameliorates post-myocardial infarction heart failure by maintaining mitochondrial calcium homeostasis via inhibiting NCLX ubiquitination
Doctor S. Li (Nanjing, CN)
Abstract Slides Video
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Myocardial delivery of a mitochondria-targeted H₂S donor restores bioenergetics and cardiac performance in diabetic cardiomyopathy
Miss Y. Yang (Beijing, CN)
Abstract Slides Video

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Mitochondrial function and metabolic remodelling in heart disease
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The Event

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ESC Congress 2026

30 August 2026 14:42 CET
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