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Targeting BRD4-HK2 reverses the meta-inflammatory shift in perivascular adipose tissue and rescues cardiometabolic vascular dysfunction.

30 August 2024 (08:00 - 17:30)
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Congress Presentation Part of: Epigenetic targets in cardiovascular disease Vascular Diseases ESC Professional Premium Access ESC Congress 2024 European Society of Cardiology

About the speaker

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Assistant Professor Alessandro Mengozzi

University of Pisa, Pisa (Italy)

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Targeting the histone methyltransferase SETD7 rescues diabetes-induced impairment of angiogenic response by transcriptional repression of semaphorin 3G
Doctor S. Mohammed (Zurich, CH)
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Chromatin remodeling by the histone methyltransferase SETD2 drives cardiometabolic heart failure with preserved ejection fraction
Doctor S. Costantino (Zurich, CH)
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Epigenetic BET inhibitor apabetalone counters inflammatory and fibrotic processes in activated cardiac fibroblasts providing insight into reduced hospitalizations for heart failure in BETonMACE trial
Doctor E. Kulikowski (Calgary, CA)
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The BET inhibitor Apabetalone protects against heart failure with preserved ejection fraction by suppressing myocardial inflammation
Doctor E. Gorica (Zurich, CH)
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RBM20 promotes doxorubicin-induced cardiotoxicity by Atp6v0a1 alternative splicing
Doctor Z. Qiu (Shanghai, CN)
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Access the full session

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Epigenetic targets in cardiovascular disease
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The Event

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ESC Congress 2024

30 August - 2 September 2024
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