The main objective of my research activities is to explore fundamental biology. My team is specifically interested on the function of the transcriptional and post-transcriptional machinery of the developing, diseased and normal myocardium. A special focus is placed on evolutionary conserved endogenous mechanisms including the nuclear Wnt signaling complexes and their role in tissue remodeling. Our models comprise preclinical animal and humanized models. We aim to exploit our gained knowledge and expertise to define disease-specific and personalized therapeutic options and to ultimately establish CRISPR-based endogenous transcription engineering to therapeutically program a homoeostatic heart. This is feasible by embedding the process in a leading, cutting-edge cardiovascular research environment using state-of-the-art technology.