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Doctor Laura Zelarayan

Georg-August-University-Göttingen, Goettingen (Germany)

The main objective of my research activities is to explore fundamental biology. My team is specifically interested on the function of the transcriptional and post-transcriptional machinery of the developing, diseased and normal myocardium. A special focus is placed on evolutionary conserved endogenous mechanisms including the nuclear Wnt signaling complexes and their role in tissue remodeling. Our models comprise preclinical animal and humanized models. We aim to exploit our gained knowledge and expertise to define disease-specific and personalized therapeutic options and to ultimately establish CRISPR-based endogenous transcription engineering to therapeutically program a homoeostatic heart. This is feasible by embedding the process in a leading, cutting-edge cardiovascular research environment using state-of-the-art technology.

CRISPR-Mediated Activation of Endogenous Gene Expression in human models.

Event: Heart Failure 2021 Online Congress

Topic: Stem Cells, Cell Cycle, Cell Senescence, Cell Death

Session: Cardiac tissue engineering from bench to bedside: are we ready?

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SHISA3: A novel Wnt signaling and KLF15 target in endothelial cell remodeling in heart failure

Event: ESC Congress 2018

Topic: Heart Failure

Session: Late Breaking Basic and Translational Science - Vascular Biology

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