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Doctor Pancras Wong

Bristol Myers Squibb, Princeton (United States of America)

Pancras Wong, PhD, FAHA, is Senior Research Fellow at Bristol-Myers Squibb Company. He received his B.A. in Chemistry from the University of Oregon and Ph.D. in Pharmacology from the University of Minnesota. He is a co-discoverer of losartan (Cozaar®), the first-in-class of antihypertensive drugs known as angiotensin II receptor blockers. His work led to the discovery of receptor subtypes for angiotensin II. He is a co-discoverer of apixaban (Eliquis®), a best-in-class oral anticoagulant (Factor Xa inhibitor), for the treatment of thrombosis. He is the author of 180 papers and 17 patents. His publications received more than 15,000 citations, leading to a Hirsh index of 57. He has received many awards, including the American Chemical Society Awards for the discovery of Cozaar® and Eliquis®, the Robert R. Ruffolo Career Achievement Award in Pharmacology from ASPET and the Sir James Black Award for Contributions to Drug Discovery from the British Pharmacological Society.

Presentations

Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys

Event: ESC Congress 2020

Topic: Antiplatelet Drugs

Session: Antithrombotic Therapy Update

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The platelet protease-activated receptor-4 antagonist, UDM-002555, alone and in combination with aspirin inhibits arterial thrombosis with limited impact on hemostasis in cynomolgus monkeys

Event: ESC Congress 2016

Topic: Thrombosis and platelets

Session: Mechanisms of platelet activation

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