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Doctor Richard Heads

King's College London, London (United Kingdom of Great Britain & Northern Ireland)

Graduated from University of Portsmouth, UK in Pharmacology. Undertook postdoctoral research in biochemistry at University of Liverpool, UK and then at University College London working on delayed preconditioning and the role of stress proteins in cardioprotection. Joined King's College London in 1996 in the department of Professor Michael Marber at The Rayne Institute, St Thomas' Hospital, London. Current Research interests: Myocardial adaption; signal transduction; assessment of cellular injury. Studying the mechanisms of adaptation, cardioprotection and cell death in cardiac myocytes and fibroblasts during ischaemia-reperfusion injury, post-infarction remodelling and heart failure. Most recently specific interests in kinase signaling in cardiac myocytes (PKC and protein kinase novel 1: PKN1) and the role of cardiac fibroblasts and tissue resident macrophages in cardiac remodeling following injury and the role of Toll receptors in mediating immunomodulation of fibroblasts.

Activation of the innate immune receptor toll-like receptor 4 (tlr4) by fibronectin fragments negatively regulates cardiac myofibroblast differentiation.

Event: Heart Failure 2017 - 4th World Congress on Acute Heart Failure

Topic: Cellular biology & cellular electrophysiology

Session: Rapid Fire 1 - Basic Science

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