Brian is a cardiologist and genetic epidemiologist who was educated and trained at Yale, Harvard, Oxford and Cambridge Universities. He is currently Professor / Director of Research in Translational Therapeutics, and Executive Director of the Centre for Naturally Randomized Trials at the University of Cambridge, UK; and Professor of Cardiovascular Medicine at the University of Milan, Italy. His previous posts included Chief of Cardiology at Wayne State University School of Medicine in the US; Chief Medical and Scientific Officer for a public-private collaboration in Beijing; and CEO of a biotechnology company. His research focuses on using Mendelian randomization to design ‘naturally randomized trials’ to generate randomized evidence that can be used to improve the drug discovery and development process; inform the optimal design of randomized trials; fill evidence gaps when a randomized trial is not possible or practical; and define the practice of precision cardiovascular medicine.