Speaker illustration

Associate Professor Atsushi Kuno

Sapporo Medical University, Second Dept. of Internal Medicine, Sapporo (Japan)

SIRT1 protects the heart against doxorubicin-induced cardiotoxicity by mediating the DNA damage response via deacetylation of histone H2AX.

Event: ESC Congress 2021 - The Digital Experience

Topic: Heart Failure

Session: Basic science e-posters


The histone deacetylase SIRT1 mediates the proper DNA repair response by targeting histone H2AX to protect against doxorubicin-induced cardiotoxicity.

Event: ESC CONGRESS 2020 - The Digital Experience

Topic: Cardio-Oncology

Session: Cardiovascular Disease in Special Populations ePosters


The SIRT1 activator resveratrol ameliorates dystrophic cardiomyopathy by promoting mitophagy.

Event: ESC Congress 2018

Topic: Mitochondria

Session: Late Breaking Basic and Translational Science - Cardiac Biology


Deletion of SIRT1 in the cardiomyocyte worsens doxorubicin-induced cardiac dysfunction in mice.

Event: ESC CONGRESS 2016

Topic: Cardiotoxicity of drugs

Session: Cardiac problems and related therapies for cancer patients


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