Associate Professor Atsushi Kuno
Sapporo Medical University, Sapporo (Japan)
SIRT1 protects the heart against doxorubicin-induced cardiotoxicity by mediating the DNA damage response via deacetylation of histone H2AX.
Event: ESC Congress 2021 - The Digital Experience
Topic: Heart Failure
Session: Basic science e-posters
The histone deacetylase SIRT1 mediates the proper DNA repair response by targeting histone H2AX to protect against doxorubicin-induced cardiotoxicity.
Event: ESC Congress 2020
Topic: Cardio-Oncology
Session: Cardiovascular Disease in Special Populations ePosters
The SIRT1 activator resveratrol ameliorates dystrophic cardiomyopathy by promoting mitophagy.
Event: ESC Congress 2018
Topic: Mitochondria
Session: Late Breaking Basic and Translational Science - Cardiac Biology
Deletion of SIRT1 in the cardiomyocyte worsens doxorubicin-induced cardiac dysfunction in mice.
Event: ESC Congress 2016
Topic: Cardiotoxicity of drugs
Session: Cardiac problems and related therapies for cancer patients
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