Professor Changjun Yin

I have been working on the topic of immune injury of chronic inflammatory diseases and am fascinated by the hypothesis that tertiary lymphoid structures (TLSs) may organize disease-specific T-cell and B-cell responses under the pathological environments. Understanding the underlying mechanisms and identification of the cognate antigens recognized by these disease-specific T-cells and B-cells are the major focus of our laboratory. We believed that these studies offer the unprecedented opportunity to understand how the immune system reacts to endogenous antigens, which are released during tissue injury under chronic inflammatory diseases, such as atherosclerosis, cancers, and Alzheimer's disease. Meanwhile, this new knowledge will lead to the next generation therapies for the benefit of patients suffering from these unresolvable diseases. Key publications in Nature Medicine (2019), Nature Cardiovascular Research (2023), Cancer Cell (2024), Gemone Medicine (2026).