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Assistant Professor Charissa van den Brom

Amsterdam University Medical Centre, Amsterdam (Netherlands (The))

I am a dedicated scientist with extended experience within the field of cardiovascular research. I am prinicpal investigator of the research line "tissue perfusion" at the departments of Anesthesiology & intensive Care Medicine. Worldwide there are not many research groups studying the pathophysiological processes of microcirculatory perfusion disturbances and acute organ injury during critical illness. The unique competences in my lab lies within the combination of state of the art physiological measurements with molecular biology of tissues and the use of innovative strategies. These strategies include a model for extracorporeal circulation, a Tie2 loss of function model, and plasma from critically ill patients in combination with an in vitro endothelial permeability assay. Therefore my translational is essential for the development of clinically applicable interventions targeting microcirculatory perfusion to protect organ function.

Protecting the endothelium to improve microcirculatory perfusion in critical illness

Event: Frontiers in CardioVascular Biomedicine 2024

Topic: Vascular Tone, Permeability, Microcirculation

Session: Bed to bench and back: insights into microvascular dysfunction from preclinical noninvasive imaging modalities

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