Doctor Frederik Ernst Deiman
University Medical Centre Groningen, Groningen (Netherlands (The))
Membership:
HFA Member
Biography
Frederik Deiman (also known as Frits Deiman) is a cardiovascular researcher interested in genetic cardiomyopathies and precision medicine. His work integrates disease modeling, patient-derived cardiac tissue, stem cell–based models, and multi-omics approaches, to elucidate disease mechanisms, identify therapeutic targets and evaluate the potential of novel drugs, particularly RNA therapy.
Contributor content
Presentation
Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy
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Presentation
Phospholamban antisense therapy reduces phospholamban aggregation and enhances calcium and contractile kinetics in human phospholamban cardiomyopathy
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Phosphoproteomics of phospholamban R14del heart tissue reveals aberrant regulation of calcium handling and contractility
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Phosphoproteomics of PLN R14del heart tissue reveals major myocyte degenerate phenotype, and is attenuated by PLN antisense treatment in vitro
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