A cardiologist by training, Isabelle Mahé is Professor of Internal Medicine at Université Paris Cité. She is Head of the Internal Medicine Department at a teaching hospital (Louis Mourier, Assistance Publique Hôpitaux de Paris, Paris, France), including an oncology unit and a vascular disease unit. She established a tele-expertise service to help physicians manage patients with anticoagulant concerns. She is also chair of the scientific council for the INNOVTE-FCRIN Network (Investigation Network On Venous Thrombo-Embolism) and for a patients' association for anticoagulant therapy (Anticoag PASS S2D). She has broad experience in methodology and in clinical trials evaluating anticoagulants in different cardiologic or vascular settings. Her own research projects have resulted in an better management of anticoagulants in complex patients (renally impaired, elderly and cancer patient). She is leading the international prospective randomised API-CAT Study (extended treatment of CAT).