Resistant hypertension and epileptic seizures: a possible modulatory role of renal denervation—a case report

Renal denervation (RDN) is an emerging therapy for selected patients with resistant hypertension. Its broader autonomic effects may extend beyond blood pressure regulation.

A 57-year-old man with resistant hypertension treated with six antihypertensive drugs and recurrent autonomic and generalized seizures underwent radiofrequency RDN. At 3 months, ambulatory blood pressure monitoring showed sustained improvement (24 h mean 139/87 mmHg), enabling therapy de-escalation. Generalized tonic–clonic seizures resolved, and autonomic/focal events markedly decreased without changes in antiepileptic medication.

This case illustrates a potential extrapressor effect of RDN mediated by modulation of sympathetic overactivity. Although causality cannot be drawn from a single case, the parallel neurological improvement supports exploring RDN’s role in conditions involving autonomic dysregulation, including certain epileptic syndromes.