Incidence and burden of cardiovascular disease attributable to extreme heat in China

European Journal of Preventive Cardiology

15 October 2025
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ESC Journals PREVENTIVE CARDIOLOGY Risk Factors and Prevention

Abstract

AbstractAims

The increasing frequency of heat events driven by climate change poses a serious challenge to cardiovascular health. This study aimed to investigate the relationship between high temperature and acute cardiovascular disease (CVD) incidence in China and to quantify the heat-related burden of CVD.

Methods and results

A total of 856 357 incident acute CVD cases were used from CVD surveillance in China in 2023. A distributed lag non-linear model was applied to evaluate the dose–response relationship between temperature and CVD incidence, as well as the best linear unbiased prediction of the minimum incidence temperature (MIT). The heat-related burden was quantified using attributable fraction and attributable number for two temperature ranges: all heat and extreme heat. Higher temperatures were associated with an increased risk of acute CVD incidence. Extreme heat exposure resulted in a cumulative relative risk (RR) of 1.17 [95% confidence interval (CI) 1.05–1.30], with the highest cumulative risk observed on the fourth day following exposure. All heat exposure accounted for 3.19% of CVD cases, while extreme heat contributed to 0.08%. The burden was particularly pronounced among individuals aged ≥65 years (RR = 1.20, 95% CI 1.05–1.37), rural populations (RR = 1.18, 95% CI 1.01–1.37), and those living in temperate monsoon and temperate continental climates (RR = 1.25, 95% CI 1.05–1.49). Minimum incidence temperature varied geographically, ranging from 16.0°C in northern regions to 26.2°C in southern regions, with the highest MITs concentrated in tropical areas.

Conclusion

These findings emphasize the urgent need for region-specific public health strategies that integrate climate change adaptation and CVD prevention to mitigate the growing health risks associated with rising temperatures.

Contributors

Muyi Sun
Muyi Sun

Author

Siyu Liu
Siyu Liu

Author

Xin Wang
Xin Wang

Author

Ye Tian
Ye Tian

Author

Xue Cao
Xue Cao

Author

Xue Yu
Xue Yu

Author

Fan Li
Fan Li

Author

Zengwu Wang
Zengwu Wang

Author

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular D Beijing , China