Successful transseptal puncture through tortuous inferior vena cava with a novel transseptal guidewire: a case report

European Heart Journal - Case Reports

7 October 2025
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ESC Journals ARRHYTHMIAS AND DEVICE THERAPY Atrial Fibrillation (AF) Interventional Cardiology

Abstract

AbstractBackground

Atrial transseptal puncture is a fundamental manoeuvre in transseptal transcatheter interventions, and inferior vena cava tortuosity could cause failure of conventional transseptal puncture method with Brockenbrough needle.

Case summary

We report a rare case of inferior vena cava tortuosity in a patient with atrial fibrillation in which the conventional transseptal puncture method failed due to marked needle deformation and was completed by a novel transseptal wire (AccuSafe™, Synaptic Medical) in combination with a steerable sheath.

Discussion

Inferior vena cava tortuosity is one of the major causes of unsuccessful atrial transseptal puncture, even under the guidance of intracardiac echocardiography. The new transseptal wire should be the initial selection rather than a conventional transseptal needle when encountering severe inferior vena cava tortuosity.

Contributors

Kai Zhang
Kai Zhang

Author

Shandong University Qilu Hospital Jinan , China