Myopericardial complications following COVID-19 disease and vaccination: a clinical consensus statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

European Heart Journal

20 May 2025
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ESC Journals CARDIOVASCULAR DISEASE IN SPECIFIC POPULATIONS IMAGING Cardiac Magnetic Resonance (CMR) Echocardiography PREVENTIVE CARDIOLOGY Risk Factors and Prevention VALVULAR, MYOCARDIAL, PERICARDIAL, PULMONARY, CONGENITAL HEART DISEASE Myocardial Disease Pericardial Disease

Abstract

Abstract

The aim of the present clinical consensus statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases is to review the current knowledge on the epidemiology, pathogenesis, diagnosis, therapy, and outcomes of myocardial and pericardial complications of coronavirus disease 2019 (COVID-19) and vaccination in order to improve the awareness and clinical confidence on the management of patients with these complications. The risk of myopericardial complications is especially higher within 1 month of COVID-19 disease and vaccination. Forms related to the disease are generally more common and severe than those related to vaccination. Even if vaccination against COVID-19 increases myocarditis risk, this risk is lower in vaccinated than non-vaccinated COVID-19 individuals, supporting the vaccine use. Overall, COVID-19 related complications, especially myocarditis, are relatively rare.

Contributors

Massimo Imazio
Massimo Imazio

Author

University Hospital Santa Maria della Misericordia Udine , Italy

Cristina Basso
Cristina Basso

Author

University of Padua Padova , Italy

Antonio Brucato
Antonio Brucato

Author

University of Milan Milan , Italy

Karin Klingel
Karin Klingel

Author

Institute for Pathology and Neuropathology Tuebingen , Germany

George Lazaros
George Lazaros

Author

National & Kapodistrian University of Athens Medical School Athens , Greece

Gianfranco Sinagra
Gianfranco Sinagra

Author

University of Trieste Trieste , Italy

Silvia Castelletti
Silvia Castelletti

Author

Hospital Santa Maria della Misericordia Udine , Italy

Alida Linda Caforio
Alida Linda Caforio

Author

University of Padua Padova , Italy

Thomas Lüscher
Thomas Lüscher

Author

Royal Brompton and Harefield NHS Foundation Trust London , United Kingdom of Great Britain & Northern Ireland