ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Joint Consensus Document on cholesterol and cardiovascular risk: diagnostic–therapeutic pathway in Italy
European Heart Journal Supplements

Abstract
Atherosclerotic cardiovascular disease still represents the leading cause of death in Western countries. A wealth of scientific evidence demonstrates that increased blood cholesterol levels have a major impact on the outbreak and progression of atherosclerotic plaques. Moreover, several cholesterol-lowering pharmacological agents, including statins and ezetimibe, have proved effective in improving clinical outcomes. This document focuses on the clinical management of hypercholesterolaemia and has been conceived by 16 Italian medical associations with the support of the Italian National Institute of Health. The authors discuss in detail the role of hypercholesterolaemia in the genesis of atherosclerotic cardiovascular disease. In addition, the implications for high cholesterol levels in the definition of the individual cardiovascular risk profile have been carefully analysed, while all available therapeutic options for blood cholesterol reduction and cardiovascular risk mitigation have been explored. Finally, this document outlines the diagnostic and therapeutic pathways for the clinical management of patients with hypercholesterolaemia.
Contributors

Furio Colivicchi
Author

Gualtiero Ricciardi
Author

Simona Giampaoli
Author

Aldo Pietro Maggioni
Author

Maurizio Averna
Author

Maria Stella Graziani
Author

Ferruccio Ceriotti
Author

Alessandro Mugelli
Author

Francesco Rossi
Author

Gerardo Medea
Author

Damiano Parretti
Author

Maurizio Giuseppe Abrignani
Author

Marcello Arca
Author

Pasquale Perrone Filardi
Author

Francesco Perticone
Author

Alberico Catapano
Author

Raffaele Griffo
Author

Federico Nardi
Author

Carmine Riccio
Author

Andrea Di Lenarda
Author

Marino Scherillo
Author

Nicoletta Musacchio
Author

Antonio Vittorio Panno
Author

Giovanni Battista Zito
Author

Mauro Campanini
Author

Leonardo Bolognese
Author

Pompilio Massimo Faggiano
Author

Giuseppe Musumeci
Author

Enrico Pusineri
Author

Marcello Ciaccio
Author

Enzo Bonora
Author

Giorgio Cantelli Forti
Author

Maria Pia Ruggieri
Author

Claudio Cricelli
Author

Francesco Romeo
Author

Roberto Ferrari
Author

Attilio Maseri
Author



