Consensus Document ANMCO/ANCE/ARCA/GICR-IACPR/GISE/SICOA: Long-term Antiplatelet Therapy in Patients with Coronary Artery Disease
European Heart Journal Supplements
Abstract
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of pharmacologic management of patients with acute coronary syndrome (ACS) and/or those receiving coronary stents. Long-term (>1 year) DAPT may further reduce the risk of stent thrombosis after a percutaneous coronary intervention (PCI) and may decrease the occurrence of non-stent-related ischaemic events in patients with ACS. Nevertheless, compared with aspirin alone, extended use of aspirin plus a P2Y12 receptor inhibitor may increase the risk of bleeding events that have been strongly linked to adverse outcomes including recurrent ischaemia, repeat hospitalisation and death. In the past years, multiple randomised trials have been published comparing the duration of DAPT after PCI and in ACS patients, investigating either a shorter or prolonged DAPT regimen. Although the current European Society of Cardiology guidelines provide a backup to individualised treatment, it appears to be difficult to identify the ideal patient profile which could safely reduce or prolong the DAPT duration in daily clinical practice. The aim of this consensus document is to review contemporary literature on optimal DAPT duration, and to guide clinicians in tailoring antiplatelet strategies in patients undergoing PCI or presenting with ACS.
Contributors
Furio Colivicchi
Author
Maurizio Giuseppe Abrignani
Author
Marco Ambrosetti
Author
Nadia Aspromonte
Author
Gabriella Barile
Author
Roberto Caporale
Author
Giancarlo Casolo
Author
Emilia Chiuini
Author
Andrea Di Lenarda
Author
Pompilio Faggiano
Author
Domenico Gabrielli
Author
Giovanna Geraci
Author
Alessio Gaetano La Manna
Author
Aldo Pietro Maggioni
Author
Alfredo Marchese
Author
Ferdinando Maria Massari
Author
Gian Francesco Mureddu
Author
Giuseppe Musumeci
Author
Federico Nardi
Author
Antonio Vittorio Panno
Author
Massimo Piredda
Author
Enrico Pusineri
Author
Carmine Riccio
Author
Roberta Rossini
Author
Fortunato Scotto di Uccio
Author
Stefano Urbinati
Author
Ferdinando Varbella
Author
Giovanni Battista Zito
Author
Leonardo De Luca
Author
Alberto Maria Cappelletti
Author
Gavino Casu
Author
Giuseppe Di Pasquale
Author
Giuseppe Di Tano
Author
Stefano Domenicucci
Author
Giuseppina Maura Francese
Author
Claudio Fresco
Author
Gian Franco Gensini
Author
Maria Teresa La Rovere
Author
Fabiana Lucà
Author
Ciro Mauro
Author
Adriano Murrone
Author
Andrea Rubboli
Author
Maria Giovanna Russo
Author
Maurizio Santomauro
Author
Corrado Tamburino
Author
Giuseppe Tarantini
Author
Ugo Vairo
Author
Guerrino Zuin
Author
Maurizio Giuseppe Abrignani
Author
Marco Ambrosetti
Author
Antonio Francesco Amico
Author
Nadia Aspromonte
Author
Vincenzo Aulitto
Author
Gabriella Barile
Author
Giacinto Calculli
Author
Pasquale Caldarola
Author
Roberto Caporale
Author
Alberto Maria Cappelletti
Author
Alessandro Carbonaro
Author
Giancarlo Casolo
Author
Gavino Casu
Author
Claudio Cavallini
Author
Emilia Chiuini
Author
Furio Colivicchi
Author
Leonardo De Luca
Author
Andrea Di Lenarda
Author
Giuseppe Di Pasquale
Author
Giuseppe Di Tano
Author
Stefano Domenicucci
Author
Pompilio Faggiano
Author
Giuseppina Maura Francese
Author
Claudio Fresco
Author
Domenico Gabrielli
Author
Gian Franco Gensini
Author
Giovanna Geraci
Author
Loreto Gesualdo
Author
Simona Giubilato
Author
Michele Massimo Gulizia
Author
Alessio Gaetano La Manna
Author
Maria Teresa La Rovere
Author
Fabiana Lucà
Author
Aldo Pietro Maggioni
Author
Alfredo Marchese
Author
Ferdinando Maria Massari
Author
Ciro Mauro
Author
Alberto Menozzi
Author
Gian Francesco Mureddu
Author
Adriano Murrone
Author
Giuseppe Musumeci
Author
Federico Nardi
Author
Patrizia Noussan
Author
Antonio Vittorio Panno
Author
Guido Parodi
Author
Gian Piero Perna
Author
Massimo Piredda
Author
Enrico Pusineri
Author
Carmine Riccio
Author
Roberta Rossini
Author
Andrea Rubboli
Author
Maria Giovanna Russo
Author
F Saia
Author
Maurizio Santomauro
Author
Marino Scherillo
Author
Giampaolo Scorcu
Author
Fortunato Scotto di Uccio
Author
Corrado Tamburino
Author
Giuseppe Tarantini
Author
Stefano Urbinati
Author
Ugo Vairo
Author
Ferdinando Varbella
Author
Giovanni Battista Zito
Author
Guerrino Zuin
Author
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