Contemporary stroke prevention strategies in 11 096 European patients with atrial fibrillation: a report from the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) Long-Term General Registry
EP Europace Journal

Abstract
Contemporary data regarding atrial fibrillation (AF) management and current use of oral anticoagulants (OACs) for stroke prevention are needed.
The EURObservational Research Programme on AF (EORP-AF) Long-Term General Registry analysed consecutive AF patients presenting to cardiologists in 250 centres from 27 European countries. From 2013 to 2016, 11 096 patients were enrolled (40.7% female; mean age 69 ± 11 years). At discharge, OACs were used in 9379 patients (84.9%), with non-vitamin K antagonists (NOACs) accounting for 40.9% of OACs. Antiplatelet therapy alone was used by 20% of patients, while no antithrombotic treatment was prescribed in 6.4%. On multivariable analysis, age, hypertension, previous ischaemic stroke, symptomatic AF and planned cardioversion or ablation were independent predictors of OAC use, whereas lone AF, previous haemorrhagic events, chronic kidney disease and admission for acute coronary syndrome (ACS) or non-cardiovascular causes independently predicted OAC non-use. Regarding the OAC type, coronary artery disease, history of heart failure, or valvular heart disease, planned cardioversion and non-AF reasons for admission independently predicted the use of vitamin K antagonists (VKAs). Wide variability among the European regions was observed in the use of NOACs, independently from other clinical factors.
The EORP-AF Long-Term General Registry provides a full picture of contemporary use of OAC in European AF patients. The overall rate of OACs use was generally high (84.9%), and a series of factors were associated with the prescription of OAC. A significant geographical heterogeneity in prescription of NOACs vs. VKAs was evident.
Contributors

Marco Proietti
Author

Cécile Laroche
Author

Laurent Fauchier
Author

Francisco Marin
Author

Michael Nabauer
Author

H Hötz
Author

T Patel
Author

Tatjana Potpara
Author

Gheorghe-Andrei Dan
Author

Zbigniew Kalarus
Author

A Korinth
Author

Igor Diemberger
Author

Luigi Tavazzi
Author

C Rheinert
Author

Aldo P Maggioni
Author

G Mehltretter
Author

E Young
Author

B Schön
Author

Gregory Y H Lip
Author

G Boriani
Author

N Schön
Author

J Law
Author

G Y H Lip
Author

A Starflinger
Author

L Tavazzi
Author

C Runnett
Author

E Englmann
Author

G Baytok
Author

A P Maggioni
Author

H Thomas
Author

T Laschinger
Author

G-A Dan
Author

H McKie
Author

G Ritscher
Author

J Fuller
Author

T Potpara
Author

M Nabauer
Author

A Gerth
Author

S Pick
Author

F Marin
Author

D Dechering
Author

L Eckardt
Author

A Sharp
Author

Z Kalarus
Author

L Fauchier
Author

A Hunt
Author

A Goda
Author

G Mairesse
Author

T Shalganov
Author

L Antoniades
Author

K Thorpe
Author

M Taborsky
Author

C Hardman
Author

S Riahi
Author

M Kuhlmann
Author

P Muda
Author

N Proskynitopoulos
Author

E Cusack
Author

I García Bolao
Author

O Piot
Author

M Nabauer
Author

J Brunn
Author

K Foth
Author

L Adams
Author

K Etsadashvili
Author

M Hough
Author

E Simantirakis
Author

S Keenan
Author

C Axthelm
Author

A Bowring
Author

H Hohensee
Author

K Eberhard
Author

S Turbanisch
Author

J Watts
Author

N Hassler
Author

J Zaman
Author

A Koestler
Author

M Haim
Author

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K Goffin
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M Haeussler-Schuchardt
Author

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Author

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A Wilson
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S Hinic
Author

S Dimkovic
Author

T Acimovic
Author

J Saric
Author

S Radovanovic
Author

A Kocijancic
Author

B Obrenovic-Kircanski
Author

D Kalimanovska Ostric
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D Simic
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I Jovanovic
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I Petrovic
Author

M Polovina
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M Vukicevic
Author

M Tomasevic
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N Mujovic
Author

N Radivojevic
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O Petrovic
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S Aleksandric
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V Kovacevic
Author

Z Mijatovic
Author

B Ivanovic
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M Tesic
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T Potpara
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A Ristic
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B Vujisic-Tesic
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M Nedeljkovic
Author

A Karadzic
Author

A Uscumlic
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M Prodanovic
Author

M Zlatar
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M Asanin
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B Bisenic
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V Vasic
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Z Popovic
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D Djikic
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M Sipic
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V Peric
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B Dejanovic
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N Milosevic
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S Backovic
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A Stevanovic
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A Andric
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B Pencic
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M Pavlovic-Kleut
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V Celic
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M Pavlovic
Author

M Petrovic
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M Vuleta
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N Petrovic
Author

S Simovic
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Z Savovic
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S Milanov
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G Davidovic
Author

V Iric-Cupic
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D Djordjevic
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M Damjanovic
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S Zdravkovic
Author

V Topic
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D Stanojevic
Author

M Randjelovic
Author

R Jankovic-Tomasevic
Author

V Atanaskovic
Author

S Antic
Author

M Pavlovic
Author

D Simonovic
Author

M Stojanovic
Author

S Stojanovic
Author

V Mitic
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V Ilic
Author

D Petrovic
Author

M Deljanin Ilic
Author

S Ilic
Author

V Stoickov
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S Markovic
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A Mijatovic
Author

D Tanasic
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D Petrovic
Author

G Radakovic
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J Peranovic
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M Pavlovic
Author

N Panic-Jelic
Author

O Vujadinovic
Author

P Pajic
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S Bekic
Author

S Kovacevic
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A García Fernandez
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A Perez Cabeza
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M Anguita
Author

L Tercedor Sanchez
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E Mau
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J Loayssa
Author

M Ayarra
Author

M Carpintero
Author

I Roldán Rabadan
Author

M Leal
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M Gil Ortega
Author

A Tello Montoliu
Author

E Orenes Piñero
Author

S Manzano Fernández
Author

F Marín
Author

A Romero Aniorte
Author

A Veliz Martínez
Author

M Quintana Giner
Author

G Ballesteros
Author

M Palacio
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O Alcalde
Author

I García-Bolao
Author

V Bertomeu Gonzalez
Author

F Otero-Raviña
Author

J García Seara
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J Gonzalez Juanatey
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N Dayal
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P Maziarski
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P Gentil-Baron
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D Shah
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M Koç
Author

E Onrat
Author

I E Dural
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K Yilmaz
Author

B özin
Author

S Tan Kurklu
Author

Y Atmaca
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U Canpolat
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L Tokgozoglu
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A K Dolu
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B Demirtas
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D Sahin
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O Ozcan Celebi
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E Diker
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G Gagirci
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H Ari
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N Polat
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N Toprak
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M Sucu
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O Akin Serdar
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A Taha Alper
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A Kepez
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Y Yuksel
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A Uzunselvi
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S Yuksel
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M Sahin
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O Kayapinar
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T Ozcan
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H Kaya
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M B Yilmaz
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M Kutlu
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M Demir
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C Gibbs
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S Kaminskiene
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M Bryce
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A Skinner
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G Belcher
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J Hunt
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L Stancombe
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B Holbrook
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C Peters
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S Tettersell
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A Shantsila
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D Lane
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K Senoo
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M Proietti
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K Russell
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P Domingos
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S Hussain
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J Partridge
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R Haynes
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S Bahadur
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R Brown
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S McMahon
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G Y H Lip
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J McDonald
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K Balachandran
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R Singh
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S Garg
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H Desai
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K Davies
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W Goddard
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G Galasko
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I Rahman
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Y Chua
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O Payne
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S Preston
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O Brennan
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L Pedley
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C Whiteside
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C Dickinson
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J Brown
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K Jones
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L Benham
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R Brady
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L Buchanan
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A Ashton
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H Crowther
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H Fairlamb
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S Thornthwaite
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C Relph
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A McSkeane
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U Poultney
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N Kelsall
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P Rice
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T Wilson
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M Wrigley
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R Kaba
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