OR77. The Struggle of Improving Ejection Fraction in Heart Failure, Does Patient Adherence Has a Significant Role? A Single-Centre Pilot Study from CORE-HF Registry

Despite the development of its treatment, adherence is an important factor in reducing the mortality and morbidity of heart failure. This study aims to see the correlation between patient adherence and improvement of ejection fraction (EF) in a Heart Failure patients.

This is a retrospective cohort study held in HF Clinic UNS Hospital from CORE-HF (COmprehensive Registry and rEsearch on Heart Failure). The adherence was measured using MMAS-8. The total score was grouped into three categories; high = 8, moderate = 6 to < 8, and poor < 6. For HFrEF patient, the EF improvement within 12 months is grouped into; Recovery (EF evaluation > 50%), improved (EF evaluation > 40%), and none (EF evaluation < 40%). For HFmrEF and HFpEF, the change of EF is categorized into increased more than 10%, < 10%, and decreased. Among 130 patients, 47.7% have poor adherence, 58% moderate adherence, and 10% high adherence. The characteristics of the samples were 60.8% male, with a mean age of 57 years old, 10% with Atrial Fibrillation, 34.6% with CAD, 36% with HFrEF, 15% with HFmrEF, and 48% patients have HFpEF. Among HFrEF, the Kruskal-Wallis test showed a statistically significant difference in EF improvement between the adherence groups (χ2 (2) = 7.860; p = 0.02). This study also found a significant difference in EF improvement among adherence groups between HFmrEF and HFpEF (χ2 (2) = 9.159; p = 0.010)

Besides optimal medical therapy, patient adherence has an important role in improving EF.