OR74. The relationship between hypertension and homocysteine level in patients with peripheral arterial disease in mataram city

Peripheral arterial disease (PAD) is a disorder or narrowing of the peripheral arteries, especially in the lower extremities due to atherosclerosis. Hyperhomocysteinemia is an independent factor in the formation of atherosclerosis. Hypertension is associated with hyperhomocysteinemia and the incidence of atherosclerosis. Data regarding plasma homocysteine levels in PAP patients with hypertension are limited. Therefore, this study aimed to investigate the comparation between hypertension and plasma homocysteine levels in PAD patients in Mataram City.

This research is a cross sectional study conducted at Siti Hajar Islamic Hospital Mataram City. The number of samples in this study was 42 samples. The study sample was a PAP subject with hypertension and an ankle brachial index (ABI) score of < 0.90. The results of this study were homocysteine levels in PAP patients with hypertension and PAP patients with non-hypertension. Analyze data using unpaired T test. Forty-two PAP patients participated in the study, with 32 samples (76.1%) female and average age 56.07 years. The average level of homocysteine in PAP patients with hypertension (6.13±0.56 μmol/L) was significantly higher than homocysteine levels in PAP patients with non-hypertension (5.18±1.14 μmol/L) (p = 0.002). Gender, age, DM history and ABI score are not associated with PAP and hypertension.

There were significant differences between average homocysteine levels in the PAP subject group with hypertension and non-hypertension.