OR50. The Prevalence of Cardiovascular Comorbidity in the Severe COVID-19 Patients and Its Correlation to Malignant Ventricular Arrhythmia, Neutrophile-Lymphocyte Ratio (NLR) and D-Dimer

This study aims to describe the prevalence of cardiovascular comorbidities and its correlation to ventricular arrhythmia, NLR and D-Dimer levels in the severe COVID-19 patients.

This study was a retrospective analytical study. The data of severe COVID-19 patients from Murni Teguh and Susanna Wesley Hospital Medan from January to May 2021 were collected. Data of cardiovascular comorbidities, cause of death, NLR, and D-dimer levels were collected. The categorical data were analysed using Chi-Square, while the numerical data were analysed using an independent T-test or Mann-Whitney test.

Ninety samples were collected. The causes of death were unshockable cardiac arrest (64.8%), ventricular arrythmia (12.2%), and septic shock (22.2%). There were 43 (47.3%) patients with cardiovascular comorbidites. Coronary arterial disease (27.5%) was the most prevalent. Any cardiovascular comorbidites (P = 0.016, OR = 5.956, CI = 1.208 – 29.370) and CAD (P = 0.044, OR = 3.789, CI = 1.309 – 13.823) were significantly related to ventricular arrythmia. The NLR-Ratio was higher in atrial fibrillation patients (42.21 ± 45.84, P = 0.031). The D-dimer level was higher in patients with any CV comorbidities (5488.47 ± 6252.22 ng/mL, P = 0.021), heart failure (5564.70 ± 9495.52 ng/mL, P = 0.033) and in hypertensive heart disease (5873.63 ± 8495.84 ng/mL, P = 0.01).

Cardiovascular comorbidities are common among severe COVID-19 patients and increase the risk of ventricular arrhythmia, NLR value in AF and D-dimer level in any CV comorbidities, HF, and HHD patients.