OR42. Hypertensive Response to Exercise as Predictor for 1-Year Rehospitalization due to Major Adverse Cardiac Event: A Putative Role of Cardiac Remodeling?

Recent studies found that hypertensive response to exercise (HRE) was associated with development of target organ damage. The study was to determine the echocardiographic parameters associated with HRE and role of HRE in rehospitalization within 1 year due to major adverse cardiac event (MACE).

This study was a cohort retrospective study using medical records of patients who underwent treadmill stress test and echocardiography examination at Sanglah General Hospital from May 2018- May 2020 which enrolled 114 patients. Data analysis used SPSS version 21. Pearson chi-square test was used to compare categorical variables based on 1-year rehospitalization after cardiac TST due to MACE that included heart failure, coronary artery disease, stroke, arrhythmia, and cardiovascular death. Mann-Whitney U test was used to compare echocardiographic parameters such as EF, EDV, ES, FS, LVIDd, LVIDs, LV mass index, LAVI, TAPSE, and E/E' ratio. Subjects with HRE had higher LV mass index (82.34±15.05 vs 70.62±9.76), higher E/E’ ratio (16.31±2.95 vs 16.01±13.23), higher LAVI (39.75±15.21 vs 34.27±11.15) with all p-value were <0.05. In this study, HRE also significantly associated with 1-year rehospitalization due to MACE (OR 2.27, 95% CI 1.62–3.16, p = 0.0001).

HRE may be used to predict 1-year rehospitalization due to MACE. In this study it was also found that HRE was associated with several echocardiographic parameters, such as LV mass index, LAVI, and E/E’ ratio. Further study is needed to determine the putative role of cardiac remodeling in patients with HRE.