Omnipolarity applied to equi-spaced electrode array for ventricular tachycardia substrate mapping

Bipolar electrogram (Bi_EGM)-based substrate maps are heavily influenced by direction of a wavefront to the mapping bipole. In this study, we evaluate high-resolution, orientation-independent peak-to-peak voltage (Vpp) maps obtained with an equi-spaced electrode array and omnipolar EGMs (OT_EGMs), measure its beat-to-beat consistency, and assess its ability to delineate diseased areas within the myocardium compared against traditional Bi_EGMs on two orientations: along (AL) and across (AC) array splines.

The endocardium of the left ventricle of 10 pigs (three healthy and seven infarcted) were each mapped using an Advisor™ HD grid with a research EnSite Precision™ system. Cardiac magnetic resonance images with late gadolinium enhancement were registered with electroanatomical maps and were used for gross scar delineation. Over healthy areas, OT_EGM Vpp values are larger than AL bipoles by 27% and AC bipoles by 26%, and over infarcted areas OT_EGM Vpp values are 23% larger than AL bipoles and 27% larger than AC bipoles (P < 0.05). Omnipolar EGM voltage maps were 37% denser than Bi_EGM maps. In addition, OT_EGM Vpp values are more consistent than bipolar Vpps showing less beat-by-beat variation than Bi_EGM by 39% and 47% over both infarcted and healthy areas, respectively (P < 0.01). Omnipolar EGM better delineate infarcted areas than traditional Bi_EGMs from both orientations.

An equi-spaced electrode grid when combined with omnipolar methodology yielded the largest detectable bipolar-like voltage and is void of directional influences, providing reliable voltage assessment within infarcted and non-infarcted regions of the heart.