AbstractGoal. To evaluate the electrophysiological changes in the LA myocardium between the stages of sequential RFA of persistent AF.
Materials and methods. From 2015 to 2018 43 patients (27 men and 16 women) underwent sequential ablation (second intervention in a period of 3 to 6 months) of persistent AF. The routine isolation was performed in the first stage. During the second stage additional lesions were performed in the areas of the restored conduction and posterior wall isolation. All patients underwent a routine EP before each stage with measurements of the atrial myocardial refractory periods, as well as intraatrial conduction.
Results. The EP parameters before the first and second stages had significantly changed: refractory periods in the areas of previously performed RFA had increased from 184 (166; 208) ms to 212 (174; 249) ms, respectively, p <0.001, the dispersion of refractivity decreased from 34 (18; 48) ms to 21 (16; 29) ms, p = 0.017. According to ECG, the duration of intraatrial conduction also decreased by 34 (24; 51) ms, p = 0.034.
Conclusion. Electrophysiological markers of intra- and interatrial conduction show a tendency to reverse modeling of atrial functions in patients passing through the staged treatment of persistent AF.
