Usefulness of the synthesized 18-lead ECG in identify the origin of premature ventricular contractions

There are have been reports on the 12-lead ECG waveforms used to identify ventricular premature contractions (VPCs), but there are not enough algorithms. On the other hand, the synthesized 18-lead ECG adds the right-side chest leads (V3R, V4R, and V5R) and back leads (V7, V8, and V9) to the 12-lead ECG.

This aim of this study was to evaluate whether the waveforms of the 18-lead ECG are useful in predicting the origin of VPCs.

We studied 86 consecutive patients (age :61.8±16.0 years, male: 54.5%) enrolled from multicenter who underwent radiofrequency catheter ablation for VPCs. We retrospectively investigated the association between origin of the VPCs and characteristics of the synthetic 18-leads ECG.

The 18-lead ECG showed a specific pattern for the VPC originating near the His-bundle. In 17 cases, the QRS morphology in V5R exhibited a QS pattern, and 13 of 17 cases had VPCs originating near the His-bundle. In the other 69 cases, V5R did not exhibit a QS pattern. ROC curve analysis showed that the QS pattern in V5R predicted VPC originating near the His-bundle with high accuracy: sensitivity 100.0%, specificity 94.5%, and AUC 0.98. Furthermore, the positive predictive value was 76.5% and negative predictive value 100.0%.

The QS pattern shown in V5R of the 18-lead ECG was a useful parameter for identifying VPCs originating near the His-bundle, which might be a good reference indicator during radiofrequency catheter ablation for VPCs.

Type of funding sources: None.