A new way to explore ventricular-arterial coupling in young patients with untreated hypertension

Commonly assessed as arterial elastance (Ea) to ventricular end-systolic elastance (Ees) ratio, ventricular-arterial coupling (VAC) has independent prognostic value in hypertension.

To investigate whether new coupling indices may be able to identify left ventricular (LV) performance changes induced by blood pressure (BP) overload earlier than conventional ones.

50 young individuals were prospectively enrolled: 25 (40±8 years) newly diagnosed untreated hypertensives and 25 controls (38±9 yrs). All underwent at the same time carotid-femoral pulse wave velocity (PWV) measurement through a tonometer and an echocardiogram to calculate global longitudinal strain (GLS) and myocardial work efficiency (GWE). Two new indices of VAC were derived: PWV/GLS, previously validated and PWV/GWE, still unknown.

ESV/SV ratio was lower in hypertensive (0.48±0.17) than in controls (0.57±0.14) but without any significant difference (p=0.18), whereas PWV/GLS was significantly lower in hypertensives than in controls (−0.45±0.19 vs −0.35±0.09 m/sec%; p=0.02). PWV/GLS ratio correlated with Ea/Ees (r=0.52; p<0.01), diastolic dysfunction degree (r=−0.59; p<0.001), age (r=−0.64; p<0.001), systolic BP (r=−0.41; p=0.002), diastolic BP (r=−0.39; p=0.005) and mean arterial pressure (MAP) (r=−0.40; p=0.004). PWV/GWE was higher in hypertensives than in controls (0.10±0.02 vs 0.08±0.01 m/sec%; p=0.001) and it was associated with Ea/Ees (r=−0.55; p=0.006), age (r=0.59; p<0.001), diastolic dysfunction degree (r=0.55; p<0.001), systolic BP (r=0.8; p<0.001), diastolic BP (r=0.5; p<0.001) and MAP (r=0.52; p<0.001).

Innovative indices of ventricular-arterial coupling could be more sensitive for investigating the impact of hypertension on LV performance.

Type of funding sources: Public hospital(s). Main funding source(s): G. Martino University Hospital, Department of Clinical and Experimental Medicine - Cardiology Unit, University of Messina, Messina, Italy