Funding AcknowledgementsType of funding sources: None.
Background. Patients with ischemic heart diseases form the majority group of cardiac diseases. Studies on the roles and mechanisms of microRNAs taking part in cardiac pathophysiology have become the focus of research worldwide.
Purpose. To elucidate whether microRNAs could be markers of atherosclerotic lesions, and further explore the mechanism of microRNAs in ischemic heart diseases.
Methods. In general, 40 patients were investigated in our Clinic. Blood tests, echocardiography (with two-dimensional speckle tracking echocardiography), ECG, coronary angiograms, microRNA detection were conducted. The patients were divided into two groups, i.e., a control group (Group A) without atherosclerotic lesion and a group with proven coronary artery disease (Group В). The data were analyzed using SPSS Statistics 20.0
Results. According to the level of circulating microRNA, a significant association between miR-122 and coronary artery lesion was identified (р=0.033). The results are shown in Figure 1. Besides, the positive moderate correlation was also revealed (r= 0.337, р=0.036). These data show miR-122 as a robust biomarker for predicting atherosclerosis lesions, and it plays certain role in pathogenesis of atherosclerosis.
Conclusion. Particularly, microRNA-122 fulfils the criteria of good biomarkers due to their key-role in severity assessment. The correlation between obtained coronary artery lesion results and epigenetic markers was found. The circulating microRNA has also improved the predictive power for diagnostics of ischemic heart disease, which is crucially important for patients and possible biochemical markers for control of treatment. Abstract Figure.
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