Poster No. 110 History of venous thromboembolic disease: a prognostic risk marker following STEMI? Insights of the French SCALIM registry

Venous and arterial thrombosis are two different entities. However, they share common risk factors and a continuum between arterial and venous thrombosis has been suggested. The purpose of our study was to determine whether a history venous thromboembolic disease (VTE) is associated with poorer outcome in patients with ST-elevation myocardial infarction (STEMI).

All consecutive STEMI patients between 2011 and 2019 were included in our regional SCALIM registry. Clinical history of VTE was collected at baseline. The primary outcome was cardiovascular mortality and recurrent non-fatal arterial events (including non-fatal-myocardial infarction, ischemic stroke and peripheral ischemic event) at 5-year follow-up. The secondary outcome was total mortality.

A total of 1924 patients (64.7 ± 14.1 years; 75.1% men) were included, among whom 2.8% with history of VTE. The latter were older than those without VTE (respectively 72.8 ± 14.1 vs. 64.4 ± 14.0 years; P < 0.001) and had more often hypertension, history of stroke and cancer. We found no statistical difference between the two groups regarding the 5-year cardiovascular mortality (11.3% vs. 7.1%, P = 0.231) and recurrent non-fatal arterial events (17.0% vs. 14.9%, P = 0.754). Five-year all-cause mortality was significantly higher in patients with history of VTE (33.3% vs. 14.6%, P = 0.001).

In a nested case-control study adjusted for age, no difference was found in primary and secondary outcomes according to VTE history.

We found no impact of history of VTE on 5-year cardiovascular outcome in who had STEMI patients. Higher mortality in these patients are related to older age and comorbidities.