Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries
European Heart Journal
Abstract
Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality.
We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66–75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%;
Considerable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare during hospitalization.
Contributors
M Linschoten
Author
A Uijl
Author
A Schut
Author
C E M Jakob
Author
L R Romão
Author
R M Bell
Author
E McFarlane
Author
M Stecher
Author
A G M Zondag
Author
E P A van Iperen
Author
W Hermans-van Ast
Author
N C Lea
Author
J Schaap
Author
L S Jewbali
Author
P C Smits
Author
R S Patel
Author
A Aujayeb
Author
P van der Harst
Author
H J Siebelink
Author
M van Smeden
Author
S Williams
Author
L Pilgram
Author
W H van Gilst
Author
R G Tieleman
Author
B Williams
Author
F W Asselbergs
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A K Al-Ali
Author
F A Al-Muhanna
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A M Al-Rubaish
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N Y Y Al-Windy
Author
M Alkhalil
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Y A Almubarak
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A N Alnafie
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M Alshahrani
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A M Alshehri
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C Anning
Author
R L Anthonio
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E A Badings
Author
C Ball
Author
E A van Beek
Author
J M ten Berg
Author
M von Bergwelt-Baildon
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M Bianco
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O V Blagova
Author
H Bleijendaal
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W L Bor
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S Borgmann
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A J M van Boxem
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F S van den Brink
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C Bucciarelli-Ducci
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B C T van Bussel
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R Byrom-Goulthorp
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G Captur
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M Caputo
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N Charlotte
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J vom Dahl
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C E Delsing
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S Dolff
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H G R Dorman
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J T Drost
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L Eberwein
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M E Emans
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A G Er
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J B Ferreira
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M J Forner
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A Friedrichs
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