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Doctor Christopher Toepfer

(United Kingdom of Great Britain & Northern Ireland)

Chris completed his PhD at Imperial College London under the supervision of Professor Michael Ferenczi and Dr. James Sellers (NHLBI, NIH). Studying cardiac muscle regulation in health and disease. He subsequently began a Post-doc with the support of a Sir Henry Wellcome Post-Doctoral Fellowship with Professors Christine and Jonathan Seidman at Harvard Medical School and Professor Hugh Watkins at the RDM Oxford. Chris is currently supported by a BHF CRE Intermediate Transition Fellowship In Oxford to investigate the role of thick filament variants in hypertrophic cardiomyopathy (HCM). The laboratory focuses on CRISPR/Cas-9 engineering of human induced pluripotent stem cells. These cells can be differentiated into cardiomyocytes, which are used to model human heart disease in a dish.

Strength of human stem cell-based models to define cellular pathomechanisms and test drugs.

Event: ESC Congress 2021 - The Digital Experience

Topic: Basic Science

Session: What does science teach us about life with genetic heart disease?

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