After graduating with honors in Medicine at the University of Udine, Antonio Paolo Beltrami (APB) had the opportunity to move to the New York Medical College (Valhalla, NY, USA). This experience (conducted during his PhD studentship) gave him the opportunity of being a primary actor in the exciting and pioneering work on adult cardiomyocyte renewal and cardiac stem cell discovery. After three years, APB moved back to Italy and continued to focus on molecular and cellular cardiology. His main area of interest is: the role played by cardiac cell senescence in the pathophysiology of heart failure. Specifically, to study the link between loss of proteostasis and inflammasome activation, as a way to identify interventions aimed at attenuating the progression of heart failure is his main goal, at present.