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Doctor Miguel A Lopez-Unzu

National Centre for Cardiovascular Research (CNIC), Madrid (Spain)
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Biography
Miguel López-Unzu obtained his PhD at University of Malaga (Animal Biology Department) in 2021, under the supervision of Prof. Ana Carmen Durán Boyero and Prof. Borja Fernández Corujo. During his predoctoral training and first postdoctoral position at University of Malaga he has researched on the morphological diversity of the cardiac outflow tract of Vertebrates and the etiology of clinically relevant cardiac valvulopathies, the embryonic development, molecular composition, myoarchitecture of the ventricular myocardium and the development of congenital anomalies of the coronary arteries in rodent models. He also has completed two scientific stays at the Sorbonne Université (Paris). From 2022 he is a Postdoctoral Researcher at the Molecular Mechanics of the Cardiovascular System lab at CNIC studying the relationship between mutations in proteins with mechanical function and myocardium morphology, especially in pathologies such as dilated cardiomyopathy or hypertrophic cardiomyopathy.
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Titin mechanical unloading disrupts sarcomere tensional homeostasis triggering fast, non-canonical myocardial fibrosis
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Titin mechanical unloading disrupts sarcomere tensional homeostasis triggering fast, non-canonical myocardial fibrosis