After he studied medicine at the faculty of Lille, he went at the University of Nantes before obtaining his medical thesis in cardiology in 2000. At the end of his internship he spent a year at Baylor College of Medicine working on the genetic aspects of arrhythmogenic dysplasia of the right ventricle. After his return to France, he worked on cardiovascular genetics and more particularly on degenerative conduction disorders, identifying the first gene involved in this pathology. He then worked on the genetics of valvular pathology with the identification of the first gene for mitral valve prolapse (FLNA) and the first large families of aortic stenosis. His work enabled him to defend his science thesis in 2003. He then became professor of cardiology in 2005 and continued his work on the genetics of sudden death, leading to the establishment of the first reference center for rhythmic diseases in France in 2004 and later the first reference center for unexplained sudden death.