The SGLT2 inhibitor ertugliflozin causes a switch of cardiac substrate utilization leading to reduced cardiac mTOR-signaling, unfolded protein response and apoptosis.
Event:
ESC Congress 2021 - The Digital Experience
Topic:
Cardiac Hypertrophy
Session:
Congress committee e-posters choice in basic science
Empagliflozin improves left ventricular diastolic function in db/db mice without altering cardiac expression of enzymes relevant for ketone body or branched chain amino acid catabolism.
Event:
ESC Congress 2018
Topic:
Pharmacotherapy
Session:
Targeting reverse remodelling in heart failure
Myocardial infarction is sufficient to increase GLP-1 secretion leading to improved left ventricular contractility and mitochondrial respiratory capacity
Event:
Heart Failure 2018
Topic:
Pathophysiology and Mechanisms
Session:
Acute Heart Failure – Pathophysiology and Mechanisms