Professor Simon Lebek

Professor Simon Lebek

University Hospital Regensburg, Regensburg (Germany)

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Prof. Dr. Simon Lebek, FESC studied Medicine in Regensburg (Germany), where he received his doctoral degree in the laboratory of Prof. Dr. Lars Maier by studying myocardial function and pathology in various cardiac disorders. After completing his habilitation in Experimental Internal Medicine, Dr. Lebek joined the laboratory of Prof. Dr. Eric Olson at the UTSW Medical Center in Dallas (USA), funded by the Walter Benjamin-fellowship of the German Research Foundation (DFG). There, he deployed CRISPR-Cas9 gene editing to disrupt pathogenic signaling as a therapeutic strategy for common cardiovascular diseases. In 2023, Simon Lebek was admitted to the DFG Heisenberg Program, which enabled him to launch an independent laboratory in Regensburg. Since April 2024, he is a Professor of Internal Medicine, Experimental Cardiology, and Gene Editing at the University Hospital Regensburg.

Presentations

CRISPR/Cas9 editing of CaMKII as a strategy for cardioprotection against ischemia/reperfusion injury.

Event: ESC Congress 2022

Topic: Ischaemia, Infarction, Cardioprotection

Session: Basic and Translational Late-Breaking Science 1

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Increased NaV1.8 expression in patients with sleep-disordered breathing induces pro-arrhythmic activity

Event: ESC Congress 2021 - The Digital Experience

Topic: Arrhythmias

Session: Basic science e-posters

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Abnormal P-waves found in patients with sleep-disordered breathing are associated with triggered pro-arrhythmic activity

Event: ESC Congress 2020

Topic: Arrhythmias

Session: New Insights into Arrhythmogenesis

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C-reactive protein as a predictor for diastolic dysfunction in patients with sleep-disordered breathing

Event: ESC Congress 2019

Topic: Comorbidities

Session: Comorbidities in heart failure

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A novel mouse model of sleep-disordered breathing is associated with contractile dysfunction and CaMKII overexpression

Event: ESC Congress 2019

Topic: Heart Failure

Session: Other cardiovascular disease

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Sleep-disordered breathing is associated with enhanced CaMKII-dependent late INa and pro-arrhythmic activity

Event: ESC Congress 2018

Topic: Arrhythmias

Session: Cardiac arrhythmias

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Professor Simon Lebek

Biography

Contributor content

CRISPR/Cas9 editing of CaMKII as a strategy for cardioprotection against ischemia/reperfusion injury.

Increased NaV1.8 expression in patients with sleep-disordered breathing induces pro-arrhythmic activity

Abnormal P-waves found in patients with sleep-disordered breathing are associated with triggered pro-arrhythmic activity

C-reactive protein as a predictor for diastolic dysfunction in patients with sleep-disordered breathing

A novel mouse model of sleep-disordered breathing is associated with contractile dysfunction and CaMKII overexpression

Sleep-disordered breathing is associated with enhanced CaMKII-dependent late INa and pro-arrhythmic activity

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