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Professor Thomas Krieg

University of Cambridge, Cambridge (United Kingdom of Great Britain & Northern Ireland)

Member of:

European Society of Cardiology

Thomas Krieg is Clinical Professor at the University of Cambridge. His research activity is around mitochondrial metabolism and redox regulation in ischema/reperfusion injury during heart attack and stroke. Much of his work has been done in collaboration with Mike Murphy in Cambridge where they identified the accumulation of succinate as a unique marker of tissue damage during IR injury. Recently, his work focused on the therapeutical possibilities in blocking this succinate rise with the succinate dehydrogenase inhibitor malonate. Together with Mike, they aim to develop malonate for the translation into the clinic. During his clinical work he sees patients in acute medicine at Addenbrookes Hospital and he is also a Teaching Associate at the Gonville and Caius College in Cambridge.

Mitochondrial toxicity.

Event: ESC Congress 2020

Topic: Basic Science, Other

Session: Targeting Metabolism to Mend the Heart

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Succinate metabolism as a cardioprotective target.

Event: ESC Congress 2017

Topic: Developmental and cellular biology

Session: Boosting mitochondria to better the heart

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